The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations

A. T. Portman; N. Giladi; K. L. Leenders; P. Maguire; L. Veenma-Van der Duin; J. Swart; J. Pruim; E. S. Simon; S. Hassin-Baer; A. D. Korczyn

doi:10.1212/WNL.56.12.1759

The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations

A. T. Portman, N. Giladi, K. L. Leenders^*, P. Maguire, L. Veenma-Van der Duin, J. Swart, J. Pruim, E. S. Simon, S. Hassin-Baer, A. D. Korczyn

^*Corresponding author for this work

Physiology Pharmacology

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Abstract

Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism in these two patients was shown to be pathophysiologically different than PD.

Original language	English
Pages (from-to)	1759-1762
Number of pages	4
Journal	Neurology
Volume	56
Issue number	12
DOIs	https://doi.org/10.1212/WNL.56.12.1759
State	Published - 26 Jun 2001

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abstract = "Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism in these two patients was shown to be pathophysiologically different than PD.",

author = "Portman, {A. T.} and N. Giladi and Leenders, {K. L.} and P. Maguire and {Veenma-Van der Duin}, L. and J. Swart and J. Pruim and Simon, {E. S.} and S. Hassin-Baer and Korczyn, {A. D.}",

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AU - Portman, A. T.

AU - Giladi, N.

AU - Leenders, K. L.

AU - Maguire, P.

AU - Veenma-Van der Duin, L.

AU - Swart, J.

AU - Pruim, J.

AU - Simon, E. S.

AU - Hassin-Baer, S.

AU - Korczyn, A. D.

PY - 2001/6/26

Y1 - 2001/6/26

N2 - Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism in these two patients was shown to be pathophysiologically different than PD.

AB - Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism in these two patients was shown to be pathophysiologically different than PD.

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VL - 56

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JO - Neurology

JF - Neurology

IS - 12

ER -

The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations

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