TY - JOUR
T1 - The neurotropic herpes viruses
T2 - herpes simplex and varicella-zoster
AU - Steiner, Israel
AU - Kennedy, Peter GE
AU - Pachner, Andrew R.
N1 - Funding Information:
The research reported in this Review was supported by grants to IS from the Israel Science Foundation, and the Israeli Ministry of Health, Chief Scientist. PGEK's work on VZV is supported by the Scottish Executive's Chief Scientist Office (CSO).
PY - 2007/11
Y1 - 2007/11
N2 - Herpes simplex viruses types 1 and 2 (HSV1 and HSV2) and varicella-zoster virus (VZV) establish latent infection in dorsal root ganglia for the entire life of the host. From this reservoir they can reactivate to cause human morbidity and mortality. Although the viruses vary in the clinical disorders they cause and in their molecular structure, they share several features that affect the course of infection of the human nervous system. HSV1 is the causative agent of encephalitis, corneal blindness, and several disorders of the peripheral nervous system; HSV2 is responsible for meningoencephalitis in neonates and meningitis in adults. Reactivation of VZV, the pathogen of varicella (chickenpox), is associated with herpes zoster (shingles) and central nervous system complications such as myelitis and focal vasculopathies. We review the biological, medical, and neurological aspects of acute, latent, and reactivated infections with the neurotropic herpes viruses.
AB - Herpes simplex viruses types 1 and 2 (HSV1 and HSV2) and varicella-zoster virus (VZV) establish latent infection in dorsal root ganglia for the entire life of the host. From this reservoir they can reactivate to cause human morbidity and mortality. Although the viruses vary in the clinical disorders they cause and in their molecular structure, they share several features that affect the course of infection of the human nervous system. HSV1 is the causative agent of encephalitis, corneal blindness, and several disorders of the peripheral nervous system; HSV2 is responsible for meningoencephalitis in neonates and meningitis in adults. Reactivation of VZV, the pathogen of varicella (chickenpox), is associated with herpes zoster (shingles) and central nervous system complications such as myelitis and focal vasculopathies. We review the biological, medical, and neurological aspects of acute, latent, and reactivated infections with the neurotropic herpes viruses.
UR - http://www.scopus.com/inward/record.url?scp=35248835968&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(07)70267-3
DO - 10.1016/S1474-4422(07)70267-3
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C2 - 17945155
AN - SCOPUS:35248835968
SN - 1474-4422
VL - 6
SP - 1015
EP - 1028
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 11
ER -
