The neuroprotective adenosine-activated signal transduction pathway involves activation of phospholipase C

A. Rogel, Y. Bromberg, O. Sperling, E. Zoref-Shani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We have demonstrated before that exposure of neuronal cultures to poisoning by iodoacetic acid (IAA) followed by "reperfusion" (IAA-R insult), results in severe cytotoxicity, which could be markedly attenuated by prior activation of the adenosine A1 receptors. We also have demonstrated that adenosine activates a signal transduction pathway (STP), which involves activation of PKCε and opening of KATP channels. Here, we provide proof for the involvement also of phospholipase C (PLC) in the neuronal protective adenosine-activated STP. R-PIA, a specific A1 adenosine receptor agonist, was found to enhance neuronal PLC activity and protect against the IAA-R insult. The PLC inhibitor U73122, abrogated both R-PIA-induced effects. These results demonstrate that activation of PLC is a vital step in the neuronal protective adenosine-induced STP.

Original languageEnglish
Pages (from-to)1283-1286
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume25
Issue number9-11
DOIs
StatePublished - 1 Jun 2006

Keywords

  • Adenosine
  • Iodoacetic acid
  • Neuroprotection
  • Phospholipase C (PLC)
  • Signal transduction pathway
  • U73122

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