The neuroleptic malignant syndrome: agent and host interaction

A. Shalev*, H. Munitz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


ABSTRACT This review comprises an exhaustive analysis of 120 case reports of neuroleptic malignant syndrome (NMS) representing the majority of published clinical data on this syndrome. Epidemiological, clinical and biological parameters, as well as those concerning the agent and the treatment of the syndrome, are critically evaluated on the basis of this data. The rate of neuroleptic loading is shown to play a cardinal role in the development of NMS. Rechallenge and aftercare of patients who need anti‐psychotic treatment after NMS are considered.

Original languageEnglish
Pages (from-to)337-347
Number of pages11
JournalActa Psychiatrica Scandinavica
Issue number4
StatePublished - Apr 1986


  • Neuroleptic malignant syndrome
  • adverse drug reaction
  • major side effects
  • tranquilizers


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