TY - JOUR
T1 - The mystery of motor asymmetry in Parkinson's disease
AU - Djaldetti, Ruth
AU - Ziv, Ilan
AU - Melamed, Eldad
N1 - Funding Information:
This study was supported by the National Parkinson Foundation, USA, and the Alan and Norma Aufzien Chair for Research in Parkinson's Disease, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. We thank Glenda Halliday and Heiko Braak for their comments and guidance for the histopathological data, and Mordechai Lorberboym for providing the SPECT images.
PY - 2006/9
Y1 - 2006/9
N2 - The motor symptoms of Parkinson's disease are predominantly due to progressive degeneration of nigral dopaminergic neurons. In most cases there is a substantial asymmetry of clinical symptoms from disease onset, which occurs in sporadic and in hereditary forms of the disease. However, the mechanism of such unilaterality of symptom appearance is not understood. There is only sparse information about whether symptom-side predominance is genetically coded and determined years before symptom onset, or whether it is acquired and related to side differences in vulnerability of the degenerating neurons. In this Personal View we review data for unilaterality of symptoms at different disease stages. We also discuss several pathological, genetic, environmental, and toxic possibilities for explaining the mechanism of side predominance.
AB - The motor symptoms of Parkinson's disease are predominantly due to progressive degeneration of nigral dopaminergic neurons. In most cases there is a substantial asymmetry of clinical symptoms from disease onset, which occurs in sporadic and in hereditary forms of the disease. However, the mechanism of such unilaterality of symptom appearance is not understood. There is only sparse information about whether symptom-side predominance is genetically coded and determined years before symptom onset, or whether it is acquired and related to side differences in vulnerability of the degenerating neurons. In this Personal View we review data for unilaterality of symptoms at different disease stages. We also discuss several pathological, genetic, environmental, and toxic possibilities for explaining the mechanism of side predominance.
UR - http://www.scopus.com/inward/record.url?scp=33746946918&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(06)70549-X
DO - 10.1016/S1474-4422(06)70549-X
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.comment???
AN - SCOPUS:33746946918
SN - 1474-4422
VL - 5
SP - 796
EP - 802
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 9
ER -