@article{1186e2b3daff4e94bae8920f75091fab,
title = "The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein",
abstract = "Many tumorigenic p53 mutants gain a common antigenic epitope that is recognized by the PAb-240 antibody. Database search identified the presence of this epitope in several other proteins, including several antibodies and the catalytic subunit of mouse telomerase, mTERT. These antibodies may represent a part of the previously demonstrated anti-idiotypic network built around p53. In the present study we demonstrate that the PAb-240 antibody was able to inhibit telomerase activity in extracts from both mouse and human tumor cells. The recognition of mTERT by PAb-240 is demonstrated by Western blotting and by using blocking peptides derived from mTERT. The existence of a shared epitope between mutant p53 and telomerase may suggest that the two proteins contribute to malignant transformation through a common pathway.",
keywords = "Epitope, Mutant p53, PAb-240, Telomerase",
author = "Igor Shats and Michael Milyavsky and Neta Erez and Varda Rotter",
note = "Funding Information: We thank Ari Meyerson for critical reading of the manuscript. This study was supported in part by grants from the Israel–USA Binational Science Foundation (BSF) and the German Israeli Foundation for Scientific Research and Development (GIF). V.R. is the incumbent of the Norman and Helen Asher Professorial Chair in Cancer Research at the Weizmann Institute.",
year = "2003",
month = jul,
day = "10",
doi = "10.1016/S0014-5793(03)00607-0",
language = "אנגלית",
volume = "546",
pages = "321--324",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "2-3",
}