TY - JOUR
T1 - The MORPH-R web server and software tool for predicting missing genes in biological pathways
AU - Amar, David
AU - Frades, Itziar
AU - Diels, Tim
AU - Zaltzman, David
AU - Ghatan, Netanel
AU - Hedley, Pete E.
AU - Alexandersson, Erik
AU - Tzfadia, Oren
AU - Shamir, Ron
N1 - Publisher Copyright:
© 2015 Scandinavian Plant Physiology Society.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - A biological pathway is the set of molecular entities involved in a given biological process and the interrelations among them. Even though biological pathways have been studied extensively, discovering missing genes in pathways remains a fundamental challenge. Here, we present an easy-to-use tool that allows users to run MORPH (MOdule-guided Ranking of candidate PatHway genes), an algorithm for revealing missing genes in biological pathways, and demonstrate its capabilities. MORPH supports the analysis in tomato, Arabidopsis and the two new species: rice and the newly sequenced potato genome. The new tool, called MORPH-R, is available both as a web server (at http://bioinformatics.psb.ugent.be/webtools/morph/) and as standalone software that can be used locally. In the standalone version, the user can apply the tool to new organisms using any proprietary and public data sources.
AB - A biological pathway is the set of molecular entities involved in a given biological process and the interrelations among them. Even though biological pathways have been studied extensively, discovering missing genes in pathways remains a fundamental challenge. Here, we present an easy-to-use tool that allows users to run MORPH (MOdule-guided Ranking of candidate PatHway genes), an algorithm for revealing missing genes in biological pathways, and demonstrate its capabilities. MORPH supports the analysis in tomato, Arabidopsis and the two new species: rice and the newly sequenced potato genome. The new tool, called MORPH-R, is available both as a web server (at http://bioinformatics.psb.ugent.be/webtools/morph/) and as standalone software that can be used locally. In the standalone version, the user can apply the tool to new organisms using any proprietary and public data sources.
UR - http://www.scopus.com/inward/record.url?scp=84939254170&partnerID=8YFLogxK
U2 - 10.1111/ppl.12326
DO - 10.1111/ppl.12326
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AN - SCOPUS:84939254170
SN - 0031-9317
VL - 155
SP - 12
EP - 20
JO - Physiologia Plantarum
JF - Physiologia Plantarum
IS - 1
ER -