TY - JOUR
T1 - The Molecular Revolution in Cutaneous Biology
T2 - Era of Next-Generation Sequencing
AU - Sarig, Ofer
AU - Sprecher, Eli
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017/5
Y1 - 2017/5
N2 - Like any true conceptual revolution, next-generation sequencing (NGS) has not only radically changed research and clinical practice, it has also modified scientific culture. With the possibility to investigate DNA contents of any organism and in any context, including in somatic disorders or in tissues carrying complex microbial populations, it initially seemed as if the genetic underpinning of any biological phenomenon could now be deciphered in an almost streamlined fashion. However, over the past recent years, we have once again come to understand that there is no such a thing as great opportunities without great challenges. The steadily expanding use of NGS and related applications is now facing biologists and physicians with novel technological obstacles, analytical hurdles and increasingly pressing ethical questions.
AB - Like any true conceptual revolution, next-generation sequencing (NGS) has not only radically changed research and clinical practice, it has also modified scientific culture. With the possibility to investigate DNA contents of any organism and in any context, including in somatic disorders or in tissues carrying complex microbial populations, it initially seemed as if the genetic underpinning of any biological phenomenon could now be deciphered in an almost streamlined fashion. However, over the past recent years, we have once again come to understand that there is no such a thing as great opportunities without great challenges. The steadily expanding use of NGS and related applications is now facing biologists and physicians with novel technological obstacles, analytical hurdles and increasingly pressing ethical questions.
UR - http://www.scopus.com/inward/record.url?scp=85017560954&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2016.02.818
DO - 10.1016/j.jid.2016.02.818
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C2 - 28411851
AN - SCOPUS:85017560954
SN - 0022-202X
VL - 137
SP - e79-e82
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 5
ER -