The molecular basis of resistance to the herbicide norflurazon

D. Chamovitz*, I. Pecker, J. Hirschberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

We have cloned and sequenced a gene, pds, from the cyanobacterium Synechococcus PCC7942 that is responsible for resistance to the bleaching herbicide norflurazon. A point mutation in that gene, leading to an amino acid substitution from valine to glycine in its polypeptide product, was found to confer this resistance. Previous studies with herbicide-resistant mutants have indicated that this gene encodes phytoene desaturase (PDS), a key enzyme in the biosynthesis of carotenoids. A short amino acid sequence that is homologous to conserved motifs in the binding sites for NAD(H) and NADP(H) was identified in PDS, suggesting the involvement of these dinucleotides as cofactors in phytoene desaturation.

Original languageEnglish
Pages (from-to)967-974
Number of pages8
JournalPlant Molecular Biology
Volume16
Issue number6
DOIs
StatePublished - Jun 1991
Externally publishedYes

Keywords

  • Synechococcus PCC7942
  • carotenogenesis
  • herbicide resistance
  • nicotinamide-adenine-dinucleotide
  • norflurazon
  • phytoene desaturase

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