The molal volumes of atropine and hyoscine in relation to their respective potencies

Sasson Cohen; Frank Haberman

doi:10.1111/j.1476-5381.1984.tb16236.x

The molal volumes of atropine and hyoscine in relation to their respective potencies

Sasson Cohen^*, Frank Haberman

^*Corresponding author for this work

Physiology Pharmacology

Israel Institute for Biological Research

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The partial molal volumes, , at infinite dilution of atropine and hyoscine were determined in each of eight different solvents having cohesive energy densities in the range 64 to 144 cal cm⁻³. for hyoscine in a given solvent was invariably and significantly smaller than that of atropine in the same solvent. The difference being 1.58 cm³ mol⁻¹ in the least polar solvent (n‐propylbenzene) and 4.29 cm³ mol⁻¹ in the most polar one (acetonitrile) in the series studied. It is proposed that the lower affinity of atropine relative to that of hyoscine for the muscarinic cholinoceptor could be accounted for by the relative increase in enthalpy in the adsorption of atropine to the receptor with respect to the same process with hyoscine. 1984 British Pharmacological Society

Original language	English
Pages (from-to)	807-811
Number of pages	5
Journal	British Journal of Pharmacology
Volume	83
Issue number	3
DOIs	https://doi.org/10.1111/j.1476-5381.1984.tb16236.x
State	Published - Nov 1984

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AB - The partial molal volumes, , at infinite dilution of atropine and hyoscine were determined in each of eight different solvents having cohesive energy densities in the range 64 to 144 cal cm−3. for hyoscine in a given solvent was invariably and significantly smaller than that of atropine in the same solvent. The difference being 1.58 cm3 mol−1 in the least polar solvent (n‐propylbenzene) and 4.29 cm3 mol−1 in the most polar one (acetonitrile) in the series studied. It is proposed that the lower affinity of atropine relative to that of hyoscine for the muscarinic cholinoceptor could be accounted for by the relative increase in enthalpy in the adsorption of atropine to the receptor with respect to the same process with hyoscine. 1984 British Pharmacological Society

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The molal volumes of atropine and hyoscine in relation to their respective potencies

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