The modified phenanthridine PJ34 unveils an exclusive cell-death mechanism in human cancer cells

Malka Cohen-Armon

doi:10.3390/cancers12061628

The modified phenanthridine PJ34 unveils an exclusive cell-death mechanism in human cancer cells

Malka Cohen-Armon^*

^*Corresponding author for this work

Medicine Dean & Assoc. Deans

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

This overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies in the structure of their mitotic spindle, leading to mitotic catastrophe cell death. This mechanism paves the way to a new concept of cancer therapy.

Original language	English
Article number	1628
Pages (from-to)	1-15
Number of pages	15
Journal	Cancers
Volume	12
Issue number	6
DOIs	https://doi.org/10.3390/cancers12061628
State	Published - Jun 2020

Keywords

Distorted mitotic spindles
Exclusive eradication of human cancer cells
The PARP inhibitor PJ34

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers12061628

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abstract = "This overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies in the structure of their mitotic spindle, leading to mitotic catastrophe cell death. This mechanism paves the way to a new concept of cancer therapy.",

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KW - Exclusive eradication of human cancer cells

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The modified phenanthridine PJ34 unveils an exclusive cell-death mechanism in human cancer cells

Abstract

Keywords

UN SDGs

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