TY - JOUR
T1 - The modified phenanthridine PJ34 unveils an exclusive cell-death mechanism in human cancer cells
AU - Cohen-Armon, Malka
N1 - Publisher Copyright:
© 2020 by the author. Licensee MDPI, Basel, Switzerland.
PY - 2020/6
Y1 - 2020/6
N2 - This overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies in the structure of their mitotic spindle, leading to mitotic catastrophe cell death. This mechanism paves the way to a new concept of cancer therapy.
AB - This overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies in the structure of their mitotic spindle, leading to mitotic catastrophe cell death. This mechanism paves the way to a new concept of cancer therapy.
KW - Distorted mitotic spindles
KW - Exclusive eradication of human cancer cells
KW - The PARP inhibitor PJ34
UR - http://www.scopus.com/inward/record.url?scp=85086646390&partnerID=8YFLogxK
U2 - 10.3390/cancers12061628
DO - 10.3390/cancers12061628
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C2 - 32575437
AN - SCOPUS:85086646390
SN - 2072-6694
VL - 12
SP - 1
EP - 15
JO - Cancers
JF - Cancers
IS - 6
M1 - 1628
ER -
