The mechanism of Raf activation through dimerization

Keyphrases

• Dimerization 100%
• Kinase Domain 50%
• On-state 33%
• Therapeutic Target 16%
• Drug Discovery 16%
• Clinical Significance 16%
• Structural Constraints 16%
• Cell Proliferation 16%
• Dimer Interface 16%
• Threonine 16%
• Hydrophobic Interaction 16%
• Phosphorylation Sites 16%
• Autophosphorylation 16%
• MEK-ERK Pathway 16%
• C-helix 16%
• Atomic Level 16%
• Serine Kinase 16%
• Raf-MEK-ERK 16%
• Intermolecular Stacking 16%
• RAF Kinase 16%
• A-loop 16%
• Atomic Insights 16%

Biochemistry, Genetics and Molecular Biology

• Dimerization 100%
• Kinase 50%
• Phosphotransferase 50%
• N-Terminus 16%
• Cell Proliferation 16%
• Autophosphorylation 16%
• Raf Kinase 16%
• Serine 16%
• Threonine 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Dimer 100%
• Phosphotransferase 66%
• Drug Discovery 33%
• Protein Serine Threonine Kinase 33%
• Raf Protein 33%