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The mechanism of Raf activation through dimerization
Mingzhen Zhang
, Ryan Maloney
, Hyunbum Jang
,
Ruth Nussinov
*
*
Corresponding author for this work
Human Molecular Genetics Biochemistry
National Institutes of Health
Research output
:
Contribution to journal
›
Article
›
peer-review
26
Scopus citations
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Keyphrases
Dimerization
100%
Kinase Domain
50%
On-state
33%
Therapeutic Target
16%
Drug Discovery
16%
Clinical Significance
16%
Structural Constraints
16%
Cell Proliferation
16%
Dimer Interface
16%
Threonine
16%
Hydrophobic Interaction
16%
Phosphorylation Sites
16%
Autophosphorylation
16%
MEK-ERK Pathway
16%
C-helix
16%
Atomic Level
16%
Serine Kinase
16%
Raf-MEK-ERK
16%
Intermolecular Stacking
16%
RAF Kinase
16%
A-loop
16%
Atomic Insights
16%
Biochemistry, Genetics and Molecular Biology
Dimerization
100%
Kinase
50%
Phosphotransferase
50%
N-Terminus
16%
Cell Proliferation
16%
Autophosphorylation
16%
Raf Kinase
16%
Serine
16%
Threonine
16%
Pharmacology, Toxicology and Pharmaceutical Science
Dimer
100%
Phosphotransferase
66%
Drug Discovery
33%
Protein Serine Threonine Kinase
33%
Raf Protein
33%