The mechanism of activation of MEK1 by B-Raf and KSR1

Keyphrases

• Activation Mechanism 100%
• MEK1 100%
• B-Raf 100%
• KSR1 100%
• Activation Loop 61%
• Proline-rich 22%
• Helix 16%
• Phosphorylation 16%
• Kinase Domain 5%
• Protein Kinase 5%
• Signal Transduction 5%
• Molecular Dynamics Simulation 5%
• ERK Pathway 5%
• Highly Flexible 5%
• Mechanistic Details 5%
• Raf-MEK-ERK 5%
• RAF Kinase 5%
• Active Configuration 5%
• Domain Similarity 5%

Biochemistry, Genetics and Molecular Biology

• Proline 100%
• Adenosine Triphosphate 50%
• Kinase 50%
• Phosphotransferase 50%
• Signal Transduction 25%
• Protein Kinases 25%