TY - JOUR
T1 - The matrilineal ancestry of Ashkenazi Jewry
T2 - Portrait of a recent founder event
AU - Behar, Doron M.
AU - Metspalu, Ene
AU - Kivisild, Toomas
AU - Achilli, Alessandro
AU - Hadid, Yarin
AU - Tzur, Shay
AU - Pereira, Luisa
AU - Amorim, Antonio
AU - Quintana-Murci, Lluis
AU - Majamaa, Kari
AU - Herrnstadt, Corinna
AU - Howell, Neil
AU - Balanovsky, Oleg
AU - Kutuev, Ildus
AU - Pshenichnov, Andrey
AU - Gurwitz, David
AU - Bonne-Tamir, Batsheva
AU - Torroni, Antonio
AU - Villems, Richard
AU - Skorecki, Karl
N1 - Funding Information:
We thank the individuals who provided samples for this study, the National Laboratory for the Genetics of Israeli Populations, which also provided samples, and Vered Friedman and Guennady Yudkovsky for technical assistance. This research was supported in part by Israeli Science Foundation grants (to K.S.), the Annie Chutick Endowment and Technion (to K.S.), the Estonian Science Foundation (to E.M. and T.K.), European Union Framework Programme Genemill and Genera grants (to R.V.), the Consiglio Nazionale della Ricerche–Ministro dell'Istruzione dell'Univerita e della Ricerca (CNR-MIUR) Genomica Funzionale-Legge 449/97 (to A.T.), the Fondo Investimenti Ricerca di Base 2001 (to A.T.), the Progetti Ricerca Interesse Nazionale 2005 (to A.T.), the National Science Foundation (to N.H.), and Programa Operacional Ciência, Tecnologia e Inovação (to A. Amorim).
PY - 2006/3
Y1 - 2006/3
N2 - Both the extent and location of the maternal ancestral deme from which the Ashkenazi Jewry arose remain obscure. Here, using complete sequences of the maternally inherited mitochondrial DNA (mtDNA), we show that close to one-half of Ashkenazi Jews, estimated at 8,000,000 people, can be traced back to only 4 women carrying distinct mtDNAs that are virtually absent in other populations, with the important exception of low frequencies among non-Ashkenazi Jews. We conclude that four founding mtDNAs, likely of Near Eastern ancestry, underwent major expansion(s) in Europe within the past millennium.
AB - Both the extent and location of the maternal ancestral deme from which the Ashkenazi Jewry arose remain obscure. Here, using complete sequences of the maternally inherited mitochondrial DNA (mtDNA), we show that close to one-half of Ashkenazi Jews, estimated at 8,000,000 people, can be traced back to only 4 women carrying distinct mtDNAs that are virtually absent in other populations, with the important exception of low frequencies among non-Ashkenazi Jews. We conclude that four founding mtDNAs, likely of Near Eastern ancestry, underwent major expansion(s) in Europe within the past millennium.
UR - http://www.scopus.com/inward/record.url?scp=33344474976&partnerID=8YFLogxK
U2 - 10.1086/500307
DO - 10.1086/500307
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C2 - 16404693
AN - SCOPUS:33344474976
SN - 0002-9297
VL - 78
SP - 487
EP - 497
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 3
ER -