The many etiologies of neonatal hypocalcemic seizures

Yael Levy-Shraga*, Keren Dallalzadeh, Keren Stern, Gideon Paret, Orit Pinhas-Hamiel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Seizures during the neonatal period have a broad differential diagnosis. Unlike in developing countries where hypovitaminosis D and hypocalcemia constitutes a major cause of infantile seizures, the number of neonatal seizures attributed to hypocalcemia in developed countries has decreased dramatically due to the improvement of infant formulas and vitamin D supplementation. In these countries, most infants that present with hypocalcemic seizures have underlying endocrinological etiologies rather than dietary insufficiencies. Here, we describe 3 cases of neonatal seizures due to hypocalcemia. Although the symptoms and calcium concentrations at presentation were similar in all 3 cases, the course of the disease and the final diagnosis for each were distinct. The cases are presented along with a brief review of the pathophysiology, differential diagnosis, and treatment of neonatal hypocalcemia.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalPediatric Emergency Care
Issue number3
StatePublished - 15 Mar 2015


  • Neonatal hypocalcemia
  • Seizures
  • Vitamin D


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