The male's role in the etiology of preeclampsia

Guy Gutman*, Ohad Hilly, Joseph B. Lessing, Michael J. Kupferminc, David Pauzner

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Preeclampsia is a major cause of morbidity and mortality in mothers, fetuses, and neonates worldwide, with 5%-10% of human births being affected. The cause is still uncertain, and many controversies exist concerning its management. Preeclampsia-eclampsia is due to the failure of extravillous cytotrophoblast to invade the maternal uterine spiral arteries to a sufficient depth, inducing poor vascular exchanges between the mother and the placenta. This physiological endovascular trophoblast invasion represents a remarkable immunological placental-maternal interaction. Recent data strongly indicate an important role for the male partner in the causation of this common pregnancy disorder. This review aims to discuss the relevant literature and to explain how paternal, relational and sexual factors play an important role in the etiology of preeclampsia.

Original languageEnglish
Pages (from-to)281-285
Number of pages5
Issue number4
StatePublished - Apr 2006


  • Immune system
  • Paternal
  • Preeclampsia
  • Sperm


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