The long-term prognostic significance of heart failure in sarcoidosis patients ─ a cohort study

Roie Etinger, Doron Comaneshter, Howard Amital, Arnon D. Cohen, Shmuel Tiosano*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate the proportion and the long-term prognostic significance of heart failure (HF) in sarcoidosis patients. Methods: Data extracted from a large Israeli healthcare provider’s database were used to study sarcoidosis patients and matched non-sarcoidosis controls since 2000 to 2016. The proportion of HF was compared between the groups, and the associations between sarcoidosis, HF, and all-cause mortality were assessed. Results: Included were 3,993 sarcoidosis patients and 19,856 age- and sex-matched controls. The proportion of HF patients was higher among the former (10.9% and 5.3%, respectively). A logistic regression model for multivariable analysis for covariates found sarcoidosis to be independently associated with HF (Odds Ratio (OR) 2.09 confidence interval (CI) 1.83–2.39). A total of 710 sarcoidosis patients (17.8%) and 2,121 controls (10.7%) died during the study period (p < 0.001). A multivariable survival analysis found an estimated hazard ratio (HR) of 1.84 (95%CI 1.67–2.02), indicating a significant association between sarcoidosis and risk for all-cause mortality. Our analysis also revealed a significant association between HF and risk for all-cause mortality (HR 3.05, 95%CI 2.77–3.36). Conclusions: Sarcoidosis is independently associated with HF, and both are independently associated with all-cause mortality.

Original languageEnglish
Pages (from-to)202-208
Number of pages7
JournalPostgraduate Medicine
Issue number2
StatePublished - 2021


FundersFunder number
Janssen Pharmaceuticals


    • Sarcoidosis
    • autoimmunity
    • cohort
    • heart failure
    • prognosis


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