The long and short: Non-coding RNAs in the mammalian inner ear

Tal Koffler-Brill*, Yael Noy, Karen B. Avraham

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Non-coding RNAs (ncRNAs) play a critical role in the entire body, and their mis-regulation is often associated with disease. In parallel with the advances in high-throughput sequencing technologies, there is a great deal of focus on this broad class of RNAs. Although these molecules are not translated into proteins, they are now well established as significant regulatory components in many biological pathways and pathological conditions. ncRNAs can be roughly divided into two main sub-groups based on the length of the transcript, with both the small and long non-coding RNAs having diverse regulatory functions. The smaller length group includes ribosomal RNAs (rRNA), transfer RNAs (tRNA), small nuclear RNAs (snRNA), small nucleolar RNAs (snoRNA), microRNAs (miRNA), small interfering RNAs (siRNA), and PIWI-associated RNAs (piRNA). The longer length group includes linear long non-coding RNAs (lncRNA) and circular RNAs (circRNA). This review is designed to present the different classes of small and long ncRNA molecules and describe some of their known roles in physiological and pathological conditions, as well as methods used to assess the validity and function of miRNAs and lncRNAs, with a focus on their role and functions in the inner ear, hearing and deafness.

Original languageEnglish
Article number108666
JournalHearing Research
StatePublished - Feb 2023


FundersFunder number
National Institutes of Health
National Institute on Deafness and Other Communication DisordersR01DC011835
German-Israeli Foundation for Scientific Research and Development3499/19, I-1430–415.13/2017
United States-Israel Binational Science Foundation01027150
Israel Science Foundation1763/20


    • Cochlea
    • Deafness
    • Hearing
    • Inner ear
    • Long non-coding rna
    • Microrna
    • Non-coding rna


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