The Israeli retrospective multicenter open-label study evaluating vagus nerve stimulation effcacy in children and adults

Shay Menascu, Uri Kremer, Yitzhak Schiller, Ilan Blatt, Nathan Watemberg, Marina Boxer, Hadasa Goldberg, Isabella Korn-Lubetzki, Moshe Steinberg, Bruria Ben-Zeev

Research output: Contribution to journalArticlepeer-review


Background: The management of intractable epilepsy in children and adults is challenging. For patients who do not respond to anti-epileptic drugs and are not suitable candidates for epilepsy surgery, vagal nerve stimulation (VNS) is a viable alternative for reducing seizure frequency. Methods: In this retrospective multicenter open-label study we examined the effcacy and tolerability of VNS in patients in fve adult and pediatric epilepsy centers in Israel. All patients had drug-resistant epilepsy and after VNS implantation in 2006- 2007 were followed for a minimum of 18 months. Patients were divided into two age groups: < 21 and > 21 years old. results: Fifty-six adults and children had a stimulator implanted in 2006-2007. At 18 months post-VNS implantation, none of the patients was seizure-free, 24.3% reported a reduction in seizures of ≥ 75%, 19% reported a 50-75% reduction, and 10.8% a 25-50% reduction. The best response rate occurred in patients with complex partial seizures. Among these patients, 7 reported a ≥ 75% reduction, 5 patients a 50-75% reduction, 3 patients a 25-50% reduction, and 8 patients a < 25% reduction. A comparison of the two age groups showed that the older group (< 21 years old) had fewer seizures than the younger group. conclusions: VNS is a relatively effective and safe palliative method for treating refractory epilepsy in both adults and children. It is an alternative treatment for patients with drug-resistant epilepsy, even after a relatively long disease duration, who are not candidates for localized epilepsy surgery.

Original languageEnglish
Pages (from-to)673-677
Number of pages5
JournalIsrael Medical Association Journal
Issue number11
StatePublished - Nov 2013
Externally publishedYes


  • Adults
  • Children
  • Epilepsy
  • Seizure reduction
  • Vagal nerve stimulation (VNS)


Dive into the research topics of 'The Israeli retrospective multicenter open-label study evaluating vagus nerve stimulation effcacy in children and adults'. Together they form a unique fingerprint.

Cite this