@article{0d30252e142444048b92d55d7f3f2950,
title = "The intricate involvement of the Insulin-like growth factor receptor signaling in mild traumatic brain injury in mice",
abstract = "Insulin-like growth factor-1 (IGF-1) was suggested as a potential neuroprotective treatment for traumatic brain injury (TBI) induced damage (cognitive as well as cellular). The main goal of the present study was to evaluate the role of the IGF-1R activation in spatial memory outcome following mild traumatic brain injury. mTBI-induced phosphorylation of IGF-1R, AKT and ERK1/2, in mice hippocampus, which was inhibited when mice were pretreated with the selective IGF-1R inhibitor AG1024. IGF-1 administration prevented spatial memory deficits following mTBI. Surprisingly, blocking the IGF-1R signaling in mTBI mice did not augment the spatial memory deficit. In addition, this data imply an intriguing and complex role of the IGF-1 signaling axis in the cellular and behavioral events following mTBI.",
keywords = "Akt, ERK1/2, IGF-1R, MTBI, Spatial memory, Y-maze test",
author = "Vardit Rubovitch and Shahaf Edut and Rive Sarfstein and Haim Werner and Pick, {Chaim G.}",
note = "Funding Information: This work was supported by the Adams Super Center for Brain Studies, Sackler Faculty of Medicine, Tel Aviv University . ",
year = "2010",
month = may,
doi = "10.1016/j.nbd.2010.01.021",
language = "אנגלית",
volume = "38",
pages = "299--303",
journal = "Neurobiology of Disease",
issn = "0969-9961",
publisher = "Academic Press Inc.",
number = "2",
}