The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson’s Disease

Tal Ben Shaul, Dan Frenkel*, Tanya Gurevich*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Parkinson’s disease (PD) is a prevalent neurodegenerative condition for which there are symptomatic treatments but no disease-modifying therapies (DMTs). Extensive research over the years has highlighted the need for a multi-target DMT approach in PD that recognizes the various risk factors and their intricate interplay in contributing to PD-related neurodegeneration. Widespread risk factors, such as emotional stress and metabolic factors, have increasingly become focal points of exploration. Our review aims to summarize interactions between emotional stress and selected key players in metabolism, such as insulin, as potential mechanisms underlying neurodegeneration in PD.

Original languageEnglish
Article number12409
JournalInternational Journal of Molecular Sciences
Volume25
Issue number22
DOIs
StatePublished - Nov 2024

Funding

FundersFunder number
Alphamedix
Parkinson’s Foundation
International Parkinson and Movement Disorder Society
Israel Innovation Authority
Tradis Gat
AbbVie
Medison
Tel Aviv University

    Keywords

    • diabetes
    • dopaminergic degeneration
    • insulin signaling and resistance
    • metabolic factors
    • neurodegeneration
    • neuroinflammation
    • Parkinson’s disease
    • physiological stress
    • psychological stress

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