@article{3d1cbc3d88244d98a431e17958fbfa1d,
title = "The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson{\textquoteright}s Disease",
abstract = "Parkinson{\textquoteright}s disease (PD) is a prevalent neurodegenerative condition for which there are symptomatic treatments but no disease-modifying therapies (DMTs). Extensive research over the years has highlighted the need for a multi-target DMT approach in PD that recognizes the various risk factors and their intricate interplay in contributing to PD-related neurodegeneration. Widespread risk factors, such as emotional stress and metabolic factors, have increasingly become focal points of exploration. Our review aims to summarize interactions between emotional stress and selected key players in metabolism, such as insulin, as potential mechanisms underlying neurodegeneration in PD.",
keywords = "diabetes, dopaminergic degeneration, insulin signaling and resistance, metabolic factors, neurodegeneration, neuroinflammation, Parkinson{\textquoteright}s disease, physiological stress, psychological stress",
author = "{Ben Shaul}, Tal and Dan Frenkel and Tanya Gurevich",
note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",
year = "2024",
month = nov,
doi = "10.3390/ijms252212409",
language = "אנגלית",
volume = "25",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "22",
}