TY - JOUR
T1 - The integration host factor (IHF) affects the expression of the phosphate-binding protein and of alkaline phosphatase in Escherichia coli
AU - Spira, Beny
AU - Yagil, Ezra
PY - 1999
Y1 - 1999
N2 - The genes encoding alkaline phosphatase (phoA) and the inducible inorganic phosphate transport system Pst (pstS, C,A,B,U) belong to the PHO regulon. Mutants of Escherichia coli lacking the global regulatory protein integration host factor (IHF) show an increased level of alkaline phosphatase and a decreased level of Pst. IHF binds weakly but specifically to a DNA fragment containing the promoter region of the pst operon but does not bind to a fragment that includes the promoter region of phoA. It is proposed that IHF is a positive regulator of the pst operon and as such controls indirectly the expression of phoA.
AB - The genes encoding alkaline phosphatase (phoA) and the inducible inorganic phosphate transport system Pst (pstS, C,A,B,U) belong to the PHO regulon. Mutants of Escherichia coli lacking the global regulatory protein integration host factor (IHF) show an increased level of alkaline phosphatase and a decreased level of Pst. IHF binds weakly but specifically to a DNA fragment containing the promoter region of the pst operon but does not bind to a fragment that includes the promoter region of phoA. It is proposed that IHF is a positive regulator of the pst operon and as such controls indirectly the expression of phoA.
UR - http://www.scopus.com/inward/record.url?scp=0032962924&partnerID=8YFLogxK
U2 - 10.1007/s002849900407
DO - 10.1007/s002849900407
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C2 - 9871104
AN - SCOPUS:0032962924
SN - 0343-8651
VL - 38
SP - 80
EP - 85
JO - Current Microbiology
JF - Current Microbiology
IS - 2
ER -