The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis

Haim Werner, Derek Le Roith

Research output: Contribution to journalReview articlepeer-review

Abstract

The biological actions of the insulin-like growth factors IGF-I and IGF- II are mediated by their activation of the IGF-IR, a transmembrane tyrosine kinase linked to the ras-raf-MAPK cascade. Functional IGF-IRs are required for the cell to progress through the cell cycle. Most importantly, cells lacking this receptor cannot be transformed by any of a number of dominant oncogenes, a finding that proves that the presence of the IGF-IR is important for the development of a malignant phenotype. Consistent with this role, the IGF-IR displays a potent antiapoptotic effect, both in vitro and in vivo. Because of its key role in the transformation process, the IGF-IR is actively studied as a potential therapeutic target in different types of neoplastic growth.

Original languageEnglish
Pages (from-to)71-92
Number of pages22
JournalCritical Reviews in Oncogenesis
Volume8
Issue number1
DOIs
StatePublished - 1997

Keywords

  • Cell cycle
  • Oncogene
  • Signal transduction
  • Transcription
  • Tumor suppressors
  • Tyrosine kinase
  • WT1
  • p53

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