TY - JOUR
T1 - The insulin-like growth factor-I receptor gene
T2 - a downstream target for oncogene and tumor suppressor action
AU - Werner, Haim
AU - Maor, Sharon
N1 - Funding Information:
Work in the laboratory of H.W. is supported by grants from the U.S.-Israel Binational Science Foundation and the Cooperation Program in Cancer Research of the Deutsches Krebsforschungszentrum (DKFZ) and Israel's Ministry of Science and Technology (MOST).
PY - 2006/8
Y1 - 2006/8
N2 - The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of both IGF-I and IGF-II. The IGF-IR is expressed in most transformed cells, where it displays potent antiapoptotic and cell-survival activities. IGF-IR levels are tightly regulated by the concerted action of secreted (e.g. peptide and steroid hormones, growth factors and cytokines) and cellular (e.g. transcription factors, oncogenes and tumor suppressors) factors. The mode of action of many tumor suppressors involves transcriptional suppression of the IGF-IR gene, with a subsequent reduction in cell-surface IGF-IR concentrations and IGF-I action. Loss-of-function mutation of tumor suppressors, a common theme in human cancer, can lead to aberrant regulation of IGF-IR gene expression.
AB - The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of both IGF-I and IGF-II. The IGF-IR is expressed in most transformed cells, where it displays potent antiapoptotic and cell-survival activities. IGF-IR levels are tightly regulated by the concerted action of secreted (e.g. peptide and steroid hormones, growth factors and cytokines) and cellular (e.g. transcription factors, oncogenes and tumor suppressors) factors. The mode of action of many tumor suppressors involves transcriptional suppression of the IGF-IR gene, with a subsequent reduction in cell-surface IGF-IR concentrations and IGF-I action. Loss-of-function mutation of tumor suppressors, a common theme in human cancer, can lead to aberrant regulation of IGF-IR gene expression.
UR - http://www.scopus.com/inward/record.url?scp=33746051671&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2006.06.007
DO - 10.1016/j.tem.2006.06.007
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C2 - 16815029
AN - SCOPUS:33746051671
SN - 1043-2760
VL - 17
SP - 236
EP - 242
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 6
ER -
