TY - JOUR
T1 - The innate immune system in demyelinating disease
AU - Mayo, Lior
AU - Quintana, Francisco J.
AU - Weiner, Howard L.
PY - 2012/7
Y1 - 2012/7
N2 - Demyelinating diseases such as multiple sclerosis are chronic inflammatory autoimmune diseases with a heterogeneous clinical presentation and course. Both the adaptive and the innate immune systems have been suggested to contribute to their pathogenesis and recovery. In this review, we discuss the role of the innate immune system in mediating demyelinating diseases. In particular, we provide an overview of the anti-inflammatory or pro-inflammatory functions of dendritic cells, mast cells, natural killer (NK) cells, NK-T cells, γδ T cells, microglial cells, and astrocytes. We emphasize the interaction of astroctyes with the immune system and how this interaction relates to the demyelinating pathologies. Given the pivotal role of the innate immune system, it is possible that targeting these cells may provide an effective therapeutic approach for demyelinating diseases.
AB - Demyelinating diseases such as multiple sclerosis are chronic inflammatory autoimmune diseases with a heterogeneous clinical presentation and course. Both the adaptive and the innate immune systems have been suggested to contribute to their pathogenesis and recovery. In this review, we discuss the role of the innate immune system in mediating demyelinating diseases. In particular, we provide an overview of the anti-inflammatory or pro-inflammatory functions of dendritic cells, mast cells, natural killer (NK) cells, NK-T cells, γδ T cells, microglial cells, and astrocytes. We emphasize the interaction of astroctyes with the immune system and how this interaction relates to the demyelinating pathologies. Given the pivotal role of the innate immune system, it is possible that targeting these cells may provide an effective therapeutic approach for demyelinating diseases.
KW - Astrocyte
KW - Central nervous system
KW - Demyelination
KW - Innate immunity
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=84862736732&partnerID=8YFLogxK
U2 - 10.1111/j.1600-065X.2012.01135.x
DO - 10.1111/j.1600-065X.2012.01135.x
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AN - SCOPUS:84862736732
SN - 0105-2896
VL - 248
SP - 170
EP - 187
JO - Immunological Reviews
JF - Immunological Reviews
IS - 1
ER -