The initial vasodilation and the later vasoconstriction of endothelin-1 are selective to specific vascular beds

Aaron Hoffman; Ehud Grossman; K. Peter Öhman; Eric Marks; Harry R. Keiser

doi:10.1093/ajh/3.10.789

The initial vasodilation and the later vasoconstriction of endothelin-1 are selective to specific vascular beds

Aaron Hoffman^*, Ehud Grossman, K. Peter Öhman, Eric Marks, Harry R. Keiser

^*Corresponding author for this work

Faculty of Medicine

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The regional hemodynamic effects of endothelin-1 (ET-1) were studied in Wistar-Kyoto rats. Endothelin-1 caused a transient increase in blood flow in the carotid and femoral arteries but a decrease in flow in the renal and mesenteric arteries. The resistance in the carotid and femoral beds decreased while it increased in the renal and mesenteric beds. Subsequently there was a variable increase in resistance in all vascular beds with a maximal increase in the renal bed. Thus, ET-1 initially causes a selective vasorelaxation in musculocutaneous beds but not in visceral beds; the cause of this selectivity is unknown. Am J Hypertens 1990;3:789-791.

Original language	English
Pages (from-to)	789-791
Number of pages	3
Journal	American Journal of Hypertension
Volume	3
Issue number	10
DOIs	https://doi.org/10.1093/ajh/3.10.789
State	Published - Oct 1990

Keywords

Blood flow
Endothelin
Vascular resistance

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abstract = "The regional hemodynamic effects of endothelin-1 (ET-1) were studied in Wistar-Kyoto rats. Endothelin-1 caused a transient increase in blood flow in the carotid and femoral arteries but a decrease in flow in the renal and mesenteric arteries. The resistance in the carotid and femoral beds decreased while it increased in the renal and mesenteric beds. Subsequently there was a variable increase in resistance in all vascular beds with a maximal increase in the renal bed. Thus, ET-1 initially causes a selective vasorelaxation in musculocutaneous beds but not in visceral beds; the cause of this selectivity is unknown. Am J Hypertens 1990;3:789-791.",

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AU - Keiser, Harry R.

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AB - The regional hemodynamic effects of endothelin-1 (ET-1) were studied in Wistar-Kyoto rats. Endothelin-1 caused a transient increase in blood flow in the carotid and femoral arteries but a decrease in flow in the renal and mesenteric arteries. The resistance in the carotid and femoral beds decreased while it increased in the renal and mesenteric beds. Subsequently there was a variable increase in resistance in all vascular beds with a maximal increase in the renal bed. Thus, ET-1 initially causes a selective vasorelaxation in musculocutaneous beds but not in visceral beds; the cause of this selectivity is unknown. Am J Hypertens 1990;3:789-791.

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The initial vasodilation and the later vasoconstriction of endothelin-1 are selective to specific vascular beds

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