The initial vasodilation and the later vasoconstriction of endothelin-1 are selective to specific vascular beds

Aaron Hoffman, Ehud Grossman, K. Peter Öhman, Eric Marks, Harry R. Keiser

Research output: Contribution to journalArticlepeer-review

Abstract

The regional hemodynamic effects of endothelin-1 (ET-1) were studied in Wistar-Kyoto rats. Endothelin-1 caused a transient increase in blood flow in the carotid and femoral arteries but a decrease in flow in the renal and mesenteric arteries. The resistance in the carotid and femoral beds decreased while it increased in the renal and mesenteric beds. Subsequently there was a variable increase in resistance in all vascular beds with a maximal increase in the renal bed. Thus, ET-1 initially causes a selective vasorelaxation in musculocutaneous beds but not in visceral beds; the cause of this selectivity is unknown. Am J Hypertens 1990;3:789-791.

Original languageEnglish
Pages (from-to)789-791
Number of pages3
JournalAmerican Journal of Hypertension
Volume3
Issue number10
DOIs
StatePublished - Oct 1990

Keywords

  • Blood flow
  • Endothelin
  • Vascular resistance

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