@article{560fbac66433418d9ce4529e3faa184b,
title = "The initial phase of GnRH-stimulated LH release from pituitary cells is independent of calcium entry through voltage-gated channels",
abstract = "Kinetic studies on gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) release were undertaken using rat and chicken pituitary cell cultures. In response to continuous GnRH stimulation, a biphasic pattern of LH release was demonstrated. The two phases showed different susceptibility to the voltage-gated Ca2+ channel blockers D600 and nifedipine. The first (transient) phase of LH release was unaffected by the Ca2+ channel blockers whereas the second (sustained) phase was inhibited by both drugs. These results indicate that the initial phase of LH release is independent of Ca2+ entry through voltage-gated Ca2+ channels and may depend on mobilisation of intracellular Ca2+ or entry of extracellular Ca2+ through another mechanism.",
keywords = "(Pituitary cell), Ca channel, Ca influx, Gonadotropin-releasing hormone, Hormone release, Kinetics, Luteinizing hormone",
author = "Smith, \{Colleen E.\} and I. Wakefield and King, \{Judy A.\} and Z. Naor and Millar, \{R. P.\} and Davidson, \{J. S.\}",
note = "Funding Information: We thank L. Odes for manuscriptp reparation, J. Morta for technical assistancea nd the South African Medical ResearchC ouncil for financial support. We gratefully acknowledge gifts of researchm aterialf rom Knoll, B.K. Follett, and the NIADDK.",
year = "1987",
month = dec,
day = "10",
doi = "10.1016/0014-5793(87)81167-5",
language = "אנגלית",
volume = "225",
pages = "247--250",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "1-2",
}