TY - JOUR
T1 - The inhibition of ribonucleic acid synthesis by the thiol-oxidizing agent, diamide, in Escherichia coli
AU - Zehavi-Willner, Tova
AU - Wax, Richard
AU - Kosower, Edward M.
PY - 1970/7/29
Y1 - 1970/7/29
N2 - The thiol-oxidizing agent, diamide, has been used to convert glutathione to glutathione disulfide within the cells of a stringent strain of Escherichia coli (CP 78), leading to a cessation of 14C-leucine incorporation (protein synthesis) and 3H-uracil incorporation (RNA synthesis). Parallel experiments with an isogenic relaxed strain (CP 79) gave similar results, providing evidence that glutathione is closely linked to RNA synthesis indepently of the link previously shown to protein synthesis.
AB - The thiol-oxidizing agent, diamide, has been used to convert glutathione to glutathione disulfide within the cells of a stringent strain of Escherichia coli (CP 78), leading to a cessation of 14C-leucine incorporation (protein synthesis) and 3H-uracil incorporation (RNA synthesis). Parallel experiments with an isogenic relaxed strain (CP 79) gave similar results, providing evidence that glutathione is closely linked to RNA synthesis indepently of the link previously shown to protein synthesis.
UR - http://www.scopus.com/inward/record.url?scp=49849116712&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(70)80323-4
DO - 10.1016/0014-5793(70)80323-4
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AN - SCOPUS:49849116712
SN - 0014-5793
VL - 9
SP - 100
EP - 102
JO - FEBS Letters
JF - FEBS Letters
IS - 2
ER -