"The Infinite Maze" of breast cancer, signaling pathways and radioresistance

Orit Kaidar-Person, Christine Lai, Abraham Kuten, Yazid Belkacemi

Research output: Contribution to journalReview articlepeer-review


The parallel growth in our understanding of tumor biology and genetics might be the key to understanding local recurrence after optimal treatment is applied. Data suggest that genetic alterations and breast cancer molecular subtypes have an effect on radiotherapy efficacy and that the HER2, EGFR/PI3K/Akt signaling pathways play a pivotal role in modulation of post-irradiation survival. These pathways have been found to be involved in radiosensitivity and/or radioresistance, tumor cell proliferation, and hypoxia. Therefore, affecting the functional activity of key players combined with radiotherapy might be the future of breast irradiation.

Original languageEnglish
Pages (from-to)411-418
Number of pages8
Issue number4
StatePublished - Aug 2013
Externally publishedYes


  • Breast cancer
  • Molecular subtypes
  • Radiobiology
  • Radioresistance
  • Radiotherapy


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