@inproceedings{40a4af032f014df2a70692b2047a3c33,
title = "The {"}indirect sodium-water coupling{"} hypothesis of cell volume regulation in cardiac muscle",
abstract = "Sodium ion has been traditionally conceived to be the main effector of changes in cellular volumes. Active extrusion of sodium by the Na/K pumps is considered to counterbalance the oncotic pressure of intracellular macromolecules. Development of NMR techniques for non-invasive measurement of cellular sodium and water contents has yielded new insights into cell volume regulation. The {"}indirect sodium-water coupling{"} hypothesis postulates that sodium correlates closely to changes in intracellular volume due to its extensive coupling with the transport of osmotically-active ions and molecules. Intracellular sodium and water contents change in parallel, however the coefficients that relate their trans-membranal fluxes in cardiac muscle vary widely. In limited cases, sodium-water uncoupling was observed upon attenuation of intracellular calcium and energy metabolism. This hypothesis offers an alternative mechanistic explanation that underlines the importance of additional volume-regulatory mechanisms bwsides sodium homeostasis.",
keywords = "Cardiac muscle, Cell volume, Edema, NMR spectroscopy, Sodium, Water homeostasis",
author = "Nadir Askenasy and Frankel Laboratory and Maria Tassini and Antonio Vivi and Ofer Kaplan and Gil Navon",
year = "2005",
language = "אנגלית",
isbn = "9806560620",
series = "WMSCI 2005 - The 9th World Multi-Conference on Systemics, Cybernetics and Informatics, Proceedings",
pages = "93--98",
booktitle = "WMSCI 2005 - The 9th World Multi-Conference on Systemics, Cybernetics and Informatics, Proceedings",
note = "9th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2005 ; Conference date: 10-07-2005 Through 13-07-2005",
}