The "indirect sodium-water coupling" hypothesis of cell volume regulation in cardiac muscle

Nadir Askenasy, Frankel Laboratory, Maria Tassini, Antonio Vivi, Ofer Kaplan, Gil Navon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Sodium ion has been traditionally conceived to be the main effector of changes in cellular volumes. Active extrusion of sodium by the Na/K pumps is considered to counterbalance the oncotic pressure of intracellular macromolecules. Development of NMR techniques for non-invasive measurement of cellular sodium and water contents has yielded new insights into cell volume regulation. The "indirect sodium-water coupling" hypothesis postulates that sodium correlates closely to changes in intracellular volume due to its extensive coupling with the transport of osmotically-active ions and molecules. Intracellular sodium and water contents change in parallel, however the coefficients that relate their trans-membranal fluxes in cardiac muscle vary widely. In limited cases, sodium-water uncoupling was observed upon attenuation of intracellular calcium and energy metabolism. This hypothesis offers an alternative mechanistic explanation that underlines the importance of additional volume-regulatory mechanisms bwsides sodium homeostasis.

Original languageEnglish
Title of host publicationWMSCI 2005 - The 9th World Multi-Conference on Systemics, Cybernetics and Informatics, Proceedings
Pages93-98
Number of pages6
StatePublished - 2005
Event9th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2005 - Orlando, FL, United States
Duration: 10 Jul 200513 Jul 2005

Publication series

NameWMSCI 2005 - The 9th World Multi-Conference on Systemics, Cybernetics and Informatics, Proceedings
Volume10

Conference

Conference9th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2005
Country/TerritoryUnited States
CityOrlando, FL
Period10/07/0513/07/05

Keywords

  • Cardiac muscle
  • Cell volume
  • Edema
  • NMR spectroscopy
  • Sodium
  • Water homeostasis

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