The importance of physical activity to preserve hippocampal volume in people with multiple sclerosis: a structural MRI study

Alon Kalron*, Shay Menascu, Chen Hoffmann, Anat Achiron

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: There is scarce data as to the association between physical activity and the volumes of subcortical brain regions in people with multiple sclerosis (PwMS). Objective: To compare the volumetric measures of subcortical brain structures in physically active and insufficiently active PwMS. Methods: This cross‐sectional study comprised 153 PwMS (39.3 ± 12.0 years, 68.0% female) who had undergone a complete neurological examination, computerized cognitive evaluation and brain MRI (using a high‐resolution scanner). MRI volumetric analysis was based on the FreeSurfer image analysis suite. Regions of interest included the hippocampus, amygdala, brain stem, basal ganglia, thalamus, accumbens nucleus, putamen, caudate and pallidum. Two MRI metrics, total volume (mm3) and estimated percentile of the subcortical region according to adjusted normative population, were calculated for each individual and brain region. Based on scores obtained from the Godin Leisure-Time Exercise Questionnaire, the cohort was subsequently divided into two groups, physically active (n = 77) and insufficiently active (n = 76). Results: The left hippocampus estimated percentile point significantly differentiated between active and insufficiently active PwMS (48.5 (S.D. = 32.2) vs. 36.4 (S.D. = 29.8); p = 0.004), even after controlling for disability (p = 0.011) and cognition (p = 0.021). The right hippocampal estimated percentile point was also significantly different between groups (46.7 (S.D. = 30.6) vs. 34.6 (S.D. = 30.8); p = 0.004). Subcortical volume of the right hippocampus explained 19.4% of the variance between the groups (p = 0.008), even after controlling for disability (p = 0.013) and cognition (p = 0.020). Conclusions: Our results provide evidence that PwMS who regularly participate in leisure-time physical activities maintain their hippocampal volume, regardless of their disability and cognitive capabilities.

Original languageEnglish
Pages (from-to)3723-3730
Number of pages8
JournalJournal of Neurology
Issue number12
StatePublished - Dec 2020


  • Brain volume
  • Cognition
  • Hippocampus
  • Multiple sclerosis
  • Physical activity
  • Structural MRI


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