TY - JOUR
T1 - The importance of biopsychosocial factors in the development of duodenal ulcer in a cohort of middle-aged men
AU - Medalie, Jack H.
AU - Stange, Kurt C.
AU - Zyzanski, Stephen J.
AU - Goldbourt, Uri
N1 - Funding Information:
Supported in part by PL 480 Counterpart Funds, National Institutes of Health Research Agreements 375106 and 263-MD-9322365, and assistance from the International Business Machines Corporation Scientific Center, Cambridge, MA.
PY - 1992/11/15
Y1 - 1992/11/15
N2 - This study prospectively evaluated psychosocial as well as biologic, behavioral, and demographic factors in the development of duodenal ulcer. Baseline data were collected in 1963 on 8, 458 Israeli men over age 40 years who had no history of duodenal ulcer. The subjects were followed for 5 years, and 254 reported the development of radio-graphically proven duodenal ulcer. The average annual incidence was six per 1,000 subjects. Multivariable logistic regression analysis confirmed several previously reported risk factors: smoking (odds ratio (OR) = 1.64, 95% confidence interval (Cl) 1.25-2.16), greater age (60 years and over) (OR = 1.85, 95% Cl 1.25-2.74), lower salary (OR = 1.50, 95% Cl 1.14-1.96), and lower systolic blood pressure (less than 140 mmHg) (OR = 1.58, 95% Cl 1.16-2.15). In addition, logistic regression analysis revealed a significant association of duodenal ulcer incidence with preceding measures of family stress, emotional support, and coping style. These were: increased family problems (OR = 1.60, 95% Cl 1.19-2.16), low level of perceived love and support from subject's wife (OR = 2.06, 95% Cl 1.05-4.05), and restraining retaliation when hurt by coworkers (OR = 1.89, 95% Cl 1.19-3.00). This study confirms several previously reported risk factors and underlines the importance of stress, lack of social support, and coping style In the development of duodenal ulcer. Am J Epidemiol 1992; 136: 1280-7
AB - This study prospectively evaluated psychosocial as well as biologic, behavioral, and demographic factors in the development of duodenal ulcer. Baseline data were collected in 1963 on 8, 458 Israeli men over age 40 years who had no history of duodenal ulcer. The subjects were followed for 5 years, and 254 reported the development of radio-graphically proven duodenal ulcer. The average annual incidence was six per 1,000 subjects. Multivariable logistic regression analysis confirmed several previously reported risk factors: smoking (odds ratio (OR) = 1.64, 95% confidence interval (Cl) 1.25-2.16), greater age (60 years and over) (OR = 1.85, 95% Cl 1.25-2.74), lower salary (OR = 1.50, 95% Cl 1.14-1.96), and lower systolic blood pressure (less than 140 mmHg) (OR = 1.58, 95% Cl 1.16-2.15). In addition, logistic regression analysis revealed a significant association of duodenal ulcer incidence with preceding measures of family stress, emotional support, and coping style. These were: increased family problems (OR = 1.60, 95% Cl 1.19-2.16), low level of perceived love and support from subject's wife (OR = 2.06, 95% Cl 1.05-4.05), and restraining retaliation when hurt by coworkers (OR = 1.89, 95% Cl 1.19-3.00). This study confirms several previously reported risk factors and underlines the importance of stress, lack of social support, and coping style In the development of duodenal ulcer. Am J Epidemiol 1992; 136: 1280-7
KW - Cohort studies
KW - Duodenal ulcer
KW - Risk factors
KW - Stress, psychological
UR - http://www.scopus.com/inward/record.url?scp=0027102162&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.aje.a116436
DO - 10.1093/oxfordjournals.aje.a116436
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AN - SCOPUS:0027102162
VL - 136
SP - 1280
EP - 1287
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 10
ER -