TY - JOUR
T1 - The impact of Tai Chi and Qigong mind-body exercises on motor and non-motor function and quality of life in Parkinson's disease
T2 - A systematic review and meta-analysis
AU - Song, R.
AU - Grabowska, W.
AU - Park, M.
AU - Osypiuk, K.
AU - Vergara-Diaz, G. P.
AU - Bonato, P.
AU - Hausdorff, J. M.
AU - Fox, M.
AU - Sudarsky, L. R.
AU - Macklin, E.
AU - Wayne, P. M.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/8
Y1 - 2017/8
N2 - Purpose To systematically evaluate and quantify the effects of Tai Chi/Qigong (TCQ) on motor (UPDRS III, balance, falls, Timed-Up-and-Go, and 6-Minute Walk) and non-motor (depression and cognition) function, and quality of life (QOL) in patients with Parkinson's disease (PD). Methods A systematic search in 7 electronic databases targeted clinical studies evaluating TCQ for individuals with PD published through August 2016. Meta-analysis was used to estimate effect sizes (Hedges's g) and publication bias for randomized controlled trials (RCTs). Methodological bias in RCTs was assessed by two raters. Results Our search identified 21 studies, 15 of which were RCTs with a total of 735 subjects. For RCTs, comparison groups included no treatment (n = 7, 47%) and active interventions (n = 8, 53%). Duration of TCQ ranged from 2 to 6 months. Methodological bias was low in 6 studies, moderate in 7, and high in 2. Fixed-effect models showed that TCQ was associated with significant improvement on most motor outcomes (UPDRS III [ES = −0.444, p < 0.001], balance [ES = 0.544, p < 0.001], Timed-Up-and-Go [ES = −0.341, p = 0.005], 6 MW [ES = −0.293, p = 0.06], falls [ES = −0.403, p = 0.004], as well as depression [ES = −0.457, p = 0.008] and QOL [ES = −0.393, p < 0.001], but not cognition [ES = −0.225, p = 0.477]). I2 indicated limited heterogeneity. Funnel plots suggested some degree of publication bias. Conclusion Evidence to date supports a potential benefit of TCQ for improving motor function, depression and QOL for individuals with PD, and validates the need for additional large-scale trials.
AB - Purpose To systematically evaluate and quantify the effects of Tai Chi/Qigong (TCQ) on motor (UPDRS III, balance, falls, Timed-Up-and-Go, and 6-Minute Walk) and non-motor (depression and cognition) function, and quality of life (QOL) in patients with Parkinson's disease (PD). Methods A systematic search in 7 electronic databases targeted clinical studies evaluating TCQ for individuals with PD published through August 2016. Meta-analysis was used to estimate effect sizes (Hedges's g) and publication bias for randomized controlled trials (RCTs). Methodological bias in RCTs was assessed by two raters. Results Our search identified 21 studies, 15 of which were RCTs with a total of 735 subjects. For RCTs, comparison groups included no treatment (n = 7, 47%) and active interventions (n = 8, 53%). Duration of TCQ ranged from 2 to 6 months. Methodological bias was low in 6 studies, moderate in 7, and high in 2. Fixed-effect models showed that TCQ was associated with significant improvement on most motor outcomes (UPDRS III [ES = −0.444, p < 0.001], balance [ES = 0.544, p < 0.001], Timed-Up-and-Go [ES = −0.341, p = 0.005], 6 MW [ES = −0.293, p = 0.06], falls [ES = −0.403, p = 0.004], as well as depression [ES = −0.457, p = 0.008] and QOL [ES = −0.393, p < 0.001], but not cognition [ES = −0.225, p = 0.477]). I2 indicated limited heterogeneity. Funnel plots suggested some degree of publication bias. Conclusion Evidence to date supports a potential benefit of TCQ for improving motor function, depression and QOL for individuals with PD, and validates the need for additional large-scale trials.
KW - Meta analysis
KW - Motor activity
KW - Parkinson disease
KW - Quality of life
KW - Tai Chi
UR - http://www.scopus.com/inward/record.url?scp=85020243745&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2017.05.019
DO - 10.1016/j.parkreldis.2017.05.019
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C2 - 28602515
AN - SCOPUS:85020243745
SN - 1353-8020
VL - 41
SP - 3
EP - 13
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
ER -