The impact of hormonal therapy for infertility on the age at menopause

A. Pines, I. Shapira, V. Mijatovic, E. J. Margalioth, Y. Frenkel

Research output: Contribution to journalArticlepeer-review


Objectives: To look for possible association between past history of ovulation induction and age at menopause. Design: Women attending our postmenopausal outpatient clinic were asked to fill questionnaires with demographic data, obstetrical history (including treatment for infertility), and medical details related to menopause. Patients: The study group (n=31) consisted of women with a history of ovulation induction, and a control group (n=200) included women who did not experience such intervention. Results: The age at the final menstrual bleeding was 46.4±5 in the study group, and 50±4 for the control group (P<0.001). This difference was most prominent for women who had induction of ovulation prior to age 35 years: they entered menopause at age 43.8±5 years. Smoking had a weak effect on the age at menopause (48.5±4 for current, vs. 49.9±4 for non- or past-smokers; P<0.03). Conclusions: This retrospective and preliminary study raises the question whether hormonal manipulations and ovarian over-stimulation during fertility treatments could be a risk factor for premature menopause.

Original languageEnglish
Pages (from-to)283-287
Number of pages5
Issue number4
StatePublished - 25 Apr 2002
Externally publishedYes


  • Age at menopause
  • Infertility
  • Ovulation induction
  • Premature menopause
  • Risk factors


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