The impact of Herpes simplex virus type 1 on cognitive impairments in young, healthy individuals - A historical prospective study

Eyal Fruchter, Shira Goldberg, Daphna Fenchel, Itamar Grotto, Keren Ginat, Mark Weiser

Research output: Contribution to journalArticlepeer-review


Herpes simplex virus (HSV) is a highly prevalent neurotropic virus. Although on the whole, chronic, latent or persistent infection is considered to be relatively benign, HSV infections can cause cognitive impairment during and after acute encephalitis. Some studies have documented cognitive impairment in exposed persons that is untraceable to encephalitis. Most studies have focused on these impairments in the mentally ill, mostly among individuals with schizophrenia, and only recently have studies begun to examine the impact of HSV infection on the cognition of healthy individuals.Subjects were a representative, random sample of 612 soldiers before active duty in the Israeli military (Israeli defense force - IDF), 62.2% HSV positive (n= 381) and 38.8% HSV negative (n= 231). Cognitive functioning and language abilities were compared between these groups, controlling for years of education, immigration status, and gender.Compared to soldiers who were sero-negative, soldiers who were sero-positive for HSV had significantly lower IQ scores (IQ= 97.96, SD= 15.19 vs IQ= 103.23, SD= 14.23; p. ≤. 0.001, effect size (ES)= 0.2), and significantly lower Hebrew language scores (ES= 0.1, p. ≤. 0.01). The results remained significant after removing subjects with mild depression, anxiety or personality disorders. Although we could not control for socio-economic status directly, our findings indicate that infection with HSV-1 is associated with reduced cognitive functioning in healthy individuals. This finding adds to the growing number of studies in the schizophrenia literature and indicates that many research findings seemingly characteristic of schizophrenia are related to the association between HSV exposure and cognitive functioning in general, and are not illness specific.

Original languageEnglish
Article number6524
Pages (from-to)292-296
Number of pages5
JournalSchizophrenia Research
Issue number1-2
StatePublished - 1 Oct 2015


  • Cognition
  • Herpes simplex virus (HSV)
  • Schizophrenia


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