TY - JOUR
T1 - The impact of GVHD on outcomes after adult single cord blood transplantation in European and Japanese populations
AU - Kanda, Junya
AU - Hayashi, Hiromi
AU - Ruggeri, Annalisa
AU - Kimura, Fumihiko
AU - Volt, Fernanda
AU - Takahashi, Satoshi
AU - Kako, Shinichi
AU - Tozatto-Maio, Karina
AU - Yanada, Masamitsu
AU - Sanz, Guillermo
AU - Uchida, Naoyuki
AU - Angelucci, Emanuele
AU - Kato, Seiko
AU - Mohty, Mohamad
AU - Forcade, Edouard
AU - Tanaka, Masatsugu
AU - Sierra, Jorge
AU - Ohta, Takanori
AU - Saccardi, Riccardo
AU - Fukuda, Takahiro
AU - Ichinohe, Tatsuo
AU - Kimura, Takafumi
AU - Rocha, Vanderson
AU - Okamoto, Shinichiro
AU - Nagler, Arnon
AU - Atsuta, Yoshiko
AU - Gluckman, Eliane
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022/1
Y1 - 2022/1
N2 - The impact of GVHD and graft-versus-leukemia effect in unrelated cord blood transplantation (UCBT) is controversial. In the Eurocord/ALWP EBMT and JSTCT/JDCHCT collaborative study, we evaluated the impact of GVHD on UCBT outcomes in Japanese and European registries. A total of 3,690 adult patients with acute leukemia who received their first single UCBT were included. A multivariate analysis of overall survival (OS) revealed a positive impact of grade II acute GVHD compared with grade 0-I GVHD, in the Japanese cohort (hazard ratio (HR), 0.81; P = 0.001), and an adverse impact in the European cohort (HR, 1.37; P = 0.007). A negative impact of grade III-IV acute GVHD on OS was observed regardless of registries. In the analysis of relapse, a positive impact of grade II acutes GVHD compared with grade 0–I GVHD was observed only in the Japanese cohort, regardless of disease risk. The positive impact of limited chronic GVHD on OS was observed only in the Japanese cohort. In conclusion, a positive impact of mild GVHD after a single UCBT was observed only in the Japanese cohort. This could explain the ethnic difference in UCBT outcomes and might contribute to the preference usage of UCBT in Japan.
AB - The impact of GVHD and graft-versus-leukemia effect in unrelated cord blood transplantation (UCBT) is controversial. In the Eurocord/ALWP EBMT and JSTCT/JDCHCT collaborative study, we evaluated the impact of GVHD on UCBT outcomes in Japanese and European registries. A total of 3,690 adult patients with acute leukemia who received their first single UCBT were included. A multivariate analysis of overall survival (OS) revealed a positive impact of grade II acute GVHD compared with grade 0-I GVHD, in the Japanese cohort (hazard ratio (HR), 0.81; P = 0.001), and an adverse impact in the European cohort (HR, 1.37; P = 0.007). A negative impact of grade III-IV acute GVHD on OS was observed regardless of registries. In the analysis of relapse, a positive impact of grade II acutes GVHD compared with grade 0–I GVHD was observed only in the Japanese cohort, regardless of disease risk. The positive impact of limited chronic GVHD on OS was observed only in the Japanese cohort. In conclusion, a positive impact of mild GVHD after a single UCBT was observed only in the Japanese cohort. This could explain the ethnic difference in UCBT outcomes and might contribute to the preference usage of UCBT in Japan.
UR - http://www.scopus.com/inward/record.url?scp=85116824876&partnerID=8YFLogxK
U2 - 10.1038/s41409-021-01479-4
DO - 10.1038/s41409-021-01479-4
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C2 - 34635798
AN - SCOPUS:85116824876
SN - 0268-3369
VL - 57
SP - 57
EP - 64
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 1
ER -
