@article{8061d3017db342469a6e122725af8e7a,
title = "The impact of exercise on gene regulation in association with complex trait genetics",
abstract = "Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or easily biopsied tissues. Extensive transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium has provided a unique opportunity to clarify how exercise can affect tissue-specific gene expression and further suggest how exercise adaptation may impact complex disease-associated genes. To build this map, we integrate this multi-tissue atlas of gene expression changes with gene-disease targets, genetic regulation of expression, and trait relationship data in humans. Consensus from multiple approaches prioritizes specific tissues and genes where endurance exercise impacts disease-relevant gene expression. Specifically, we identify a total of 5523 trait-tissue-gene triplets to serve as a valuable starting point for future investigations [Exercise; Transcription; Human Phenotypic Variation].",
author = "{MoTrPAC Study Group} and Vetr, {Nikolai G.} and Gay, {Nicole R.} and Adkins, {Joshua N.} and Albertson, {Brent G.} and David Amar and Amper, {Mary Anne S.} and Armenteros, {Jose Juan Almagro} and Euan Ashley and Julian Avila-Pacheco and Dam Bae and Balci, {Ali Tugrul} and Marcas Bamman and Nasim Bararpour and Barton, {Elisabeth R.} and {Jean Beltran}, {Pierre M.} and Bergman, {Bryan C.} and Bessesen, {Daniel H.} and Bodine, {Sue C.} and Booth, {Frank W.} and Brian Bouverat and Buford, {Thomas W.} and Burant, {Charles F.} and Tiziana Caputo and Steven Carr and Chambers, {Toby L.} and Clarisa Chavez and Maria Chikina and Roxanne Chiu and Michael Cicha and Clish, {Clary B.} and Coen, {Paul M.} and Dan Cooper and Elaine Cornell and Gary Cutter and Dalton, {Karen P.} and Surendra Dasari and Courtney Dennis and Karyn Esser and Evans, {Charles R.} and Roger Farrar and Fern{\'a}dez, {Facundo M.} and Kishore Gadde and Nicole Gagne and Gaul, {David A.} and Yongchao Ge and Gerszten, {Robert E.} and Goodpaster, {Bret H.} and Goodyear, {Laurie J.} and Gritsenko, {Marina A.} and Kristy Guevara",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",
year = "2024",
month = dec,
doi = "10.1038/s41467-024-45966-w",
language = "אנגלית",
volume = "15",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Research",
number = "1",
}