The impact of eustachian tube function on intra-tympanic steroid administration

Uri Chavkin, Jacob Pitaro, Haim Gavriel, Ahmed Taha, Limor Muallem Kalmovich, Shahaf Shilo, Ophir Handzel, Nidal Muhanna, Anton Warshavsky, Gilad Horowitz, Omer J. Ungar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives: This study investigated the impact of eustachian tube (ET) function (ETF) on therapeutic success on candidates for intra-tympanic administration of steroids (ITAoS), due to idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: Medical chart review in two university-affiliated medical centers was performed. Included were consecutive adult patients diagnosed with unilateral ISSNHL between 2012 and 2019 who were treated with ITAoS due to incomplete or no recovery following systemic steroidal therapy. ETF was assessed by means tympanometry, before the initiation of ITAoS. The cohort was divided into an ET dysfunction group (ETD(+)) and a functioning ET group (control: ETD(−)). The audiologic response to treatment was recorded at the last follow-up. Results: A total of 64 suitable patients [median (interquartile, IQR) age 49 (38–63) years] were enrolled. The ETD(+) group included 20 patients and the remaining 44 patients served as controls. Demographic and clinical parameters were not significantly different between the two groups at presentation. Hearing thresholds were improved significantly better, at frequencies 250, 500, 1, 2, 4, and 8 kHz (p = 0.001–0.040) in the ETD(+) group. Conclusion: ETD(+) is associated with better efficacy of ITAoS. Level of evidence: 4.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalEuropean Archives of Oto-Rhino-Laryngology
Issue number1
StatePublished - Jan 2023


  • Eustachian tube dysfunction
  • Idiopathic sudden sensorineural hearing loss
  • Intratympanic steroids injection
  • Sudden deafness


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