The impact of different types of anesthesia on in vitro fertilization-embryo transfer treatment outcome

Ofer Gonen, Adrian Shulman, Yehudit Ghetler, Arieh Shapiro, Robert Judeiken, Yoram Beyth, Isaac Ben-Nun

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Our objective was to evaluate retrospectively the influence of different types of anesthesia on the outcome of ovum retrieval. Methods: Sedation combined with local anesthesia was used on 120 occasions (Group I), epidural block in 139 ovum retrievals (Group II), and general anesthesia in 173 cycles (Group III). Results: No differences were found in embryo yield or number or the quality of the embryos transferred. Of 99 pregnancies achieved, 66 live deliveries were recorded. Significantly lower clinical pregnancy rates were found in Group III (14.5%) compared with Group II (23.7%; P= 0.018) or Group I (25.8%; P=0.0074). Highly significant differences were found in the delivery rates between Group HI (8.7%), Group II (20.11%; P=0.0017), and Group I (19.2%; P=0.0043). Conclusion: The use of general anesthesia, especially nitrous oxide, for oocyte retrieval has an adverse effect on IVF outcome. This deleterious effect manifests itself only after embryo transfer and leads to lower pregnancy and delivery rates.

Original languageEnglish
Pages (from-to)678-682
Number of pages5
JournalJournal of Assisted Reproduction and Genetics
Volume12
Issue number10
DOIs
StatePublished - Nov 1995
Externally publishedYes

Keywords

  • anesthesia
  • in vitro fertilization
  • nitrous oxide
  • ovum retrieval

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