The impact of coronary sinus narrowing on diastolic function in patients with refractory angina

Yishay Szekely, Yan Topilsky, Samuel Bazan, Miri Revivo, Shmuel Banai, Maayan Konigstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective: Evaluating the impact of Coronary sinus (CS) narrowing on diastolic function. Background: Narrowing of the CS is an emerging therapy for refractory angina pectoris, improving perfusion to the ischemic subendocardium and relieving ischemia and angina. It was speculated that increased CS pressure might cause interstitial myocardial edema and diastolic dysfunction. Methods: Prospective assessment of diastolic function was performed at baseline and 6 months following CS Reducer implantation in consecutive patients treated for refractory angina. Diastolic function assessment included left atrial volume, early transmitral filling peak velocity (E wave), E wave deceleration time (DT), transmitral atrial wave velocity (A wave), and early diastolic velocity of the septal (e′ septal) and lateral (e′ lateral) aspects of the mitral annulus. Results: Twenty-four patients with chronic refractory angina and proven myocardial ischemia (mean age 69.3 ± 10.9 years) were included in the analysis. A wave velocity, E/A ratio, E wave DT and left atrial volume did not significantly change 6 months following Reducer implantation (p > 0.1 for all comparisons). A non-significant decrease in E wave velocity (80.5 ± 22.3 cm/s vs. 75.7 ± 17.5 cm/s, p = 0.19) and non significant increase in e′ septal and lateral (5.28 ± 1.54 cm/s vs. 5.30 ± 1.71 cm/s, p = 0.95 and 8.26 ± 1.85 cm/s vs. 8.46 ± 2.07 cm/s, p = 0.69, respectively) led to a non-significant decrease in E/e′ average ratio (12.6 ± 5.7 vs. 11.4 ± 3.3, p = 0.24). Mean diastolic function class significantly decreased following Reducer implantation from 1.5 ± 0.66 to 1.17 ± 0.76 (p = 0.008). Conclusion: Coronary sinus narrowing in patients with myocardial ischemia and refractory angina does not adversely affect diastolic function and may actually improve it.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalInternational Journal of Cardiology
StatePublished - 15 Sep 2019


  • Coronary sinus Reducer
  • Coronary sinus narrowing
  • Diastolic function
  • Refractory angina


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