TY - JOUR
T1 - The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests
T2 - Impact of bariatric surgery on NAFLD
AU - Netanel, Carmit
AU - Goitein, David
AU - Rubin, Moshe
AU - Kleinbaum, Yeruham
AU - Katsherginsky, Sima
AU - Hermon, Hila
AU - Tsaraf, Keren
AU - Tachlytski, Irina
AU - Herman, Amir
AU - Safran, Michal
AU - Ben-Ari, Ziv
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/7
Y1 - 2021/7
N2 - Background: Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates. We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated non-invasive measures. Methods: Patients with morbid obesity and NAFLD, planned for SG, were evaluated before and after surgery. Data collected included anthropometrics, biochemistry, adiponectin, SteatoTest™, NashTest™, FibroTest™, OWLiver® test and real-time ShearWave™ elastography (SWE). Results: Twenty-six subjects were included in the study, mean age 44.1 ± 4.8 years, 69.2% males. One year following SG, body mass index decreased significantly from 41.7 ± 4.8 kg/m2 to 29.6 ± 4.5 kg/m2. Concomitantly, significant improvements in triglycerides, ALT, diabetes markers and adiponectin were observed. Mean steatosis, as measured by SteatoTest™, was significantly improved. Steatohepatitis score measured by NashTest™ and OWLiver® significantly decreased. Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not change over time. Conclusion: Steatosis and steatohepatitis are significantly improved by SG as measured by non-invasive measures.
AB - Background: Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates. We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated non-invasive measures. Methods: Patients with morbid obesity and NAFLD, planned for SG, were evaluated before and after surgery. Data collected included anthropometrics, biochemistry, adiponectin, SteatoTest™, NashTest™, FibroTest™, OWLiver® test and real-time ShearWave™ elastography (SWE). Results: Twenty-six subjects were included in the study, mean age 44.1 ± 4.8 years, 69.2% males. One year following SG, body mass index decreased significantly from 41.7 ± 4.8 kg/m2 to 29.6 ± 4.5 kg/m2. Concomitantly, significant improvements in triglycerides, ALT, diabetes markers and adiponectin were observed. Mean steatosis, as measured by SteatoTest™, was significantly improved. Steatohepatitis score measured by NashTest™ and OWLiver® significantly decreased. Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not change over time. Conclusion: Steatosis and steatohepatitis are significantly improved by SG as measured by non-invasive measures.
KW - Bariatric surgery
KW - Non-invasive tests
KW - Nonalcoholic fatty liver disease
KW - Nonalcoholic-steatohepatitis
KW - Steatosis
UR - http://www.scopus.com/inward/record.url?scp=85097450641&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2020.11.045
DO - 10.1016/j.amjsurg.2020.11.045
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C2 - 33309037
AN - SCOPUS:85097450641
SN - 0002-9610
VL - 222
SP - 214
EP - 219
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 1
ER -
