The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests: Impact of bariatric surgery on NAFLD

Carmit Netanel, David Goitein, Moshe Rubin, Yeruham Kleinbaum, Sima Katsherginsky, Hila Hermon, Keren Tsaraf, Irina Tachlytski, Amir Herman, Michal Safran, Ziv Ben-Ari

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates. We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated non-invasive measures. Methods: Patients with morbid obesity and NAFLD, planned for SG, were evaluated before and after surgery. Data collected included anthropometrics, biochemistry, adiponectin, SteatoTest™, NashTest™, FibroTest™, OWLiver® test and real-time ShearWave™ elastography (SWE). Results: Twenty-six subjects were included in the study, mean age 44.1 ± 4.8 years, 69.2% males. One year following SG, body mass index decreased significantly from 41.7 ± 4.8 kg/m2 to 29.6 ± 4.5 kg/m2. Concomitantly, significant improvements in triglycerides, ALT, diabetes markers and adiponectin were observed. Mean steatosis, as measured by SteatoTest™, was significantly improved. Steatohepatitis score measured by NashTest™ and OWLiver® significantly decreased. Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not change over time. Conclusion: Steatosis and steatohepatitis are significantly improved by SG as measured by non-invasive measures.

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalAmerican Journal of Surgery
Volume222
Issue number1
DOIs
StatePublished - Jul 2021

Keywords

  • Bariatric surgery
  • Non-invasive tests
  • Nonalcoholic fatty liver disease
  • Nonalcoholic-steatohepatitis
  • Steatosis

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