Abstract
Familial Mediterranean fever (FMF) is a genetic disorder with an obscure aetiology. In attempts to investigate a possible immunoregulatory imbalance involved in this disease we tested 24 FMF patients for suppressor T cell activity and for chemotaxis of mononuclear cells. The suppressor T cell activity and chemotaxis were decreased in untreated FMF patients as compared to colchicine treated patients or normal controls. Amyloid FMF patients manifested significantly increased chemotactic activity, while the suppressor T cell activity was normal. This finding may extend our knowledge concerning the immune mechanism involved in FMF.
| Original language | English |
|---|---|
| Pages (from-to) | 659-662 |
| Number of pages | 4 |
| Journal | Clinical and Experimental Immunology |
| Volume | 53 |
| Issue number | 3 |
| State | Published - 1983 |