The immune system in familial Mediterranean fever

I. Melamed, Y. Shemer, V. Zakuth, E. Tzehoval, M. Pras, Z. Spirer

Research output: Contribution to journalArticlepeer-review


Familial Mediterranean fever (FMF) is a genetic disorder with an obscure aetiology. In attempts to investigate a possible immunoregulatory imbalance involved in this disease we tested 24 FMF patients for suppressor T cell activity and for chemotaxis of mononuclear cells. The suppressor T cell activity and chemotaxis were decreased in untreated FMF patients as compared to colchicine treated patients or normal controls. Amyloid FMF patients manifested significantly increased chemotactic activity, while the suppressor T cell activity was normal. This finding may extend our knowledge concerning the immune mechanism involved in FMF.

Original languageEnglish
Pages (from-to)659-662
Number of pages4
JournalClinical and Experimental Immunology
Issue number3
StatePublished - 1983


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