The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II

Santanu Kumar Ghosh, Soumitra Sau, Sudeshna Lahiri, Anuradha Lohia, Pratima Sinha*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The mitotic kinetochore of the budding yeast contains a number of proteins which are required for chromosome transmission but are non-essential for vegetative growth. We show that one such protein, Im13, is essential for meiosis, in that the absence of this protein results in reduced spore viability, precocious sister chromatid segregation of artificial and natural chromosomes in meiosis I and chromosome non-disjunction in meiosis II.

Original languageEnglish
Pages (from-to)82-91
Number of pages10
JournalCurrent Genetics
Volume46
Issue number2
DOIs
StatePublished - Aug 2004
Externally publishedYes

Keywords

  • Iml3
  • Meiosis I
  • Precocious separation of sister chromatids
  • Yeast mutant

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