Abstract
Recent efforts have pin-pointed a relevant sequence on gliadin, that may act as the immunodominant epitope in celiac disease. Independent reports from several leading laboratories identify a 33 amino acid segment spanning through residues 57-89, and excessively rich in proline and glutamine, as the putative epitope. A glutamine residue in position 65 is the site of deamidation by transglutaminase, promoting its recognition by DQ2-HLA. In addition, another gluten protein, glutenin, may be relevant to the pathogenesis in celiac disease.
| Original language | English |
|---|---|
| Pages (from-to) | 554-557+564 |
| Journal | Harefuah |
| Volume | 142 |
| Issue number | 7 |
| State | Published - 1 Jul 2003 |
| Externally published | Yes |
Keywords
- Celiac
- DQ2-HLA
- Gliadin
- Glutenin
- Transglutaminase