The identification of the immunodominant gliadin epitope

B. Sela*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Recent efforts have pin-pointed a relevant sequence on gliadin, that may act as the immunodominant epitope in celiac disease. Independent reports from several leading laboratories identify a 33 amino acid segment spanning through residues 57-89, and excessively rich in proline and glutamine, as the putative epitope. A glutamine residue in position 65 is the site of deamidation by transglutaminase, promoting its recognition by DQ2-HLA. In addition, another gluten protein, glutenin, may be relevant to the pathogenesis in celiac disease.

Original languageEnglish
Pages (from-to)554-557+564
Issue number7
StatePublished - 1 Jul 2003
Externally publishedYes


  • Celiac
  • DQ2-HLA
  • Gliadin
  • Glutenin
  • Transglutaminase


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