The human tumor microbiome is composed of tumor type-specific intracellular bacteria

Deborah Nejman; Ilana Livyatan; Garold Fuks; Nancy Gavert; Yaara Zwang; Leore T. Geller; Aviva Rotter-Maskowitz; Roi Weiser; Giuseppe Mallel; Elinor Gigi; Arnon Meltser; Gavin M. Douglas; Iris Kamer; Vancheswaran Gopalakrishnan; Tali Dadosh; Smadar Levin-Zaidman; Sofia Avnet; Tehila Atlan; Zachary A. Cooper; Reetakshi Arora; Alexandria P. Cogdill; Md Abdul Wadud Khan; Gabriel Ologun; Yuval Bussi; Adina Weinberger; Maya Lotan-Pompan; Ofra Golani; Gili Perry; Merav Rokah; Keren Bahar-Shany; Elisa A. Rozeman; Christian U. Blank; Anat Ronai; Ron Shaoul; Amnon Amit; Tatiana Dorfman; Ran Kremer; Zvi R. Cohen; Sagi Harnof; Tali Siegal; Einav Yehuda-Shnaidman; Einav Nili Gal-Yam; Hagit Shapira; Nicola Baldini; Morgan G.I. Langille; Alon Ben-Nun; Bella Kaufman; Aviram Nissan; Talia Golan; Maya Dadiani; Keren Levanon; Jair Bar; Shlomit Katz Yust; Iris Barshack; Daniel S. Peeper; Dan J. Raz; Eran Segal; Jennifer A. Wargo; Judith Sandbank; Noam Shental; Ravid Straussman

doi:10.1126/science.aay9189

The human tumor microbiome is composed of tumor type-specific intracellular bacteria

Deborah Nejman, Ilana Livyatan, Garold Fuks, Nancy Gavert, Yaara Zwang, Leore T. Geller, Aviva Rotter-Maskowitz, Roi Weiser, Giuseppe Mallel, Elinor Gigi, Arnon Meltser, Gavin M. Douglas, Iris Kamer, Vancheswaran Gopalakrishnan, Tali Dadosh, Smadar Levin-Zaidman, Sofia Avnet, Tehila Atlan, Zachary A. Cooper, Reetakshi AroraAlexandria P. Cogdill, Md Abdul Wadud Khan, Gabriel Ologun, Yuval Bussi, Adina Weinberger, Maya Lotan-Pompan, Ofra Golani, Gili Perry, Merav Rokah, Keren Bahar-Shany, Elisa A. Rozeman, Christian U. Blank, Anat Ronai, Ron Shaoul, Amnon Amit, Tatiana Dorfman, Ran Kremer, Zvi R. Cohen, Sagi Harnof, Tali Siegal, Einav Yehuda-Shnaidman, Einav Nili Gal-Yam, Hagit Shapira, Nicola Baldini, Morgan G.I. Langille, Alon Ben-Nun, Bella Kaufman, Aviram Nissan, Talia Golan, Maya Dadiani, Keren Levanon, Jair Bar, Shlomit Katz Yust, Iris Barshack, Daniel S. Peeper, Dan J. Raz, Eran Segal, Jennifer A. Wargo, Judith Sandbank, Noam Shental, Ravid Straussman^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.

Original language	English
Pages (from-to)	973-980
Number of pages	8
Journal	Science
Volume	368
Issue number	6494
DOIs	https://doi.org/10.1126/science.aay9189
State	Published - 29 May 2020

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10.1126/science.aay9189

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Nejman, D., Livyatan, I., Fuks, G., Gavert, N., Zwang, Y., Geller, L. T., Rotter-Maskowitz, A., Weiser, R., Mallel, G., Gigi, E., Meltser, A., Douglas, G. M., Kamer, I., Gopalakrishnan, V., Dadosh, T., Levin-Zaidman, S., Avnet, S., Atlan, T., Cooper, Z. A., ... Straussman, R. (2020). The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science, 368(6494), 973-980. https://doi.org/10.1126/science.aay9189

@article{0d853f84b5ab46de86fb2243bce6601a,

title = "The human tumor microbiome is composed of tumor type-specific intracellular bacteria",

abstract = "Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.",

author = "Deborah Nejman and Ilana Livyatan and Garold Fuks and Nancy Gavert and Yaara Zwang and Geller, {Leore T.} and Aviva Rotter-Maskowitz and Roi Weiser and Giuseppe Mallel and Elinor Gigi and Arnon Meltser and Douglas, {Gavin M.} and Iris Kamer and Vancheswaran Gopalakrishnan and Tali Dadosh and Smadar Levin-Zaidman and Sofia Avnet and Tehila Atlan and Cooper, {Zachary A.} and Reetakshi Arora and Cogdill, {Alexandria P.} and Khan, {Md Abdul Wadud} and Gabriel Ologun and Yuval Bussi and Adina Weinberger and Maya Lotan-Pompan and Ofra Golani and Gili Perry and Merav Rokah and Keren Bahar-Shany and Rozeman, {Elisa A.} and Blank, {Christian U.} and Anat Ronai and Ron Shaoul and Amnon Amit and Tatiana Dorfman and Ran Kremer and Cohen, {Zvi R.} and Sagi Harnof and Tali Siegal and Einav Yehuda-Shnaidman and Gal-Yam, {Einav Nili} and Hagit Shapira and Nicola Baldini and Langille, {Morgan G.I.} and Alon Ben-Nun and Bella Kaufman and Aviram Nissan and Talia Golan and Maya Dadiani and Keren Levanon and Jair Bar and Yust, {Shlomit Katz} and Iris Barshack and Peeper, {Daniel S.} and Raz, {Dan J.} and Eran Segal and Wargo, {Jennifer A.} and Judith Sandbank and Noam Shental and Ravid Straussman",

year = "2020",

month = may,

day = "29",

doi = "10.1126/science.aay9189",

language = "אנגלית",

volume = "368",

pages = "973--980",

journal = "Science",

issn = "0036-8075",

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Nejman, D, Livyatan, I, Fuks, G, Gavert, N, Zwang, Y, Geller, LT, Rotter-Maskowitz, A, Weiser, R, Mallel, G, Gigi, E, Meltser, A, Douglas, GM, Kamer, I, Gopalakrishnan, V, Dadosh, T, Levin-Zaidman, S, Avnet, S, Atlan, T, Cooper, ZA, Arora, R, Cogdill, AP, Khan, MAW, Ologun, G, Bussi, Y, Weinberger, A, Lotan-Pompan, M, Golani, O, Perry, G, Rokah, M, Bahar-Shany, K, Rozeman, EA, Blank, CU, Ronai, A, Shaoul, R, Amit, A, Dorfman, T, Kremer, R, Cohen, ZR, Harnof, S, Siegal, T, Yehuda-Shnaidman, E, Gal-Yam, EN, Shapira, H, Baldini, N, Langille, MGI, Ben-Nun, A, Kaufman, B, Nissan, A, Golan, T, Dadiani, M, Levanon, K, Bar, J, Yust, SK, Barshack, I, Peeper, DS, Raz, DJ, Segal, E, Wargo, JA, Sandbank, J, Shental, N & Straussman, R 2020, 'The human tumor microbiome is composed of tumor type-specific intracellular bacteria', Science, vol. 368, no. 6494, pp. 973-980. https://doi.org/10.1126/science.aay9189

TY - JOUR

T1 - The human tumor microbiome is composed of tumor type-specific intracellular bacteria

AU - Nejman, Deborah

AU - Livyatan, Ilana

AU - Fuks, Garold

AU - Gavert, Nancy

AU - Zwang, Yaara

AU - Geller, Leore T.

AU - Rotter-Maskowitz, Aviva

AU - Weiser, Roi

AU - Mallel, Giuseppe

AU - Gigi, Elinor

AU - Meltser, Arnon

AU - Douglas, Gavin M.

AU - Kamer, Iris

AU - Gopalakrishnan, Vancheswaran

AU - Dadosh, Tali

AU - Levin-Zaidman, Smadar

AU - Avnet, Sofia

AU - Atlan, Tehila

AU - Cooper, Zachary A.

AU - Arora, Reetakshi

AU - Cogdill, Alexandria P.

AU - Khan, Md Abdul Wadud

AU - Ologun, Gabriel

AU - Bussi, Yuval

AU - Weinberger, Adina

AU - Lotan-Pompan, Maya

AU - Golani, Ofra

AU - Perry, Gili

AU - Rokah, Merav

AU - Bahar-Shany, Keren

AU - Rozeman, Elisa A.

AU - Blank, Christian U.

AU - Ronai, Anat

AU - Shaoul, Ron

AU - Amit, Amnon

AU - Dorfman, Tatiana

AU - Kremer, Ran

AU - Cohen, Zvi R.

AU - Harnof, Sagi

AU - Siegal, Tali

AU - Yehuda-Shnaidman, Einav

AU - Gal-Yam, Einav Nili

AU - Shapira, Hagit

AU - Baldini, Nicola

AU - Langille, Morgan G.I.

AU - Ben-Nun, Alon

AU - Kaufman, Bella

AU - Nissan, Aviram

AU - Golan, Talia

AU - Dadiani, Maya

AU - Levanon, Keren

AU - Bar, Jair

AU - Yust, Shlomit Katz

AU - Barshack, Iris

AU - Peeper, Daniel S.

AU - Raz, Dan J.

AU - Segal, Eran

AU - Wargo, Jennifer A.

AU - Sandbank, Judith

AU - Shental, Noam

AU - Straussman, Ravid

PY - 2020/5/29

Y1 - 2020/5/29

N2 - Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.

AB - Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.

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U2 - 10.1126/science.aay9189

DO - 10.1126/science.aay9189

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C2 - 32467386

AN - SCOPUS:85085635900

SN - 0036-8075

VL - 368

SP - 973

EP - 980

JO - Science

JF - Science

IS - 6494

ER -

The human tumor microbiome is composed of tumor type-specific intracellular bacteria

Abstract

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