TY - JOUR
T1 - The heme biosynthetic pathway in the regenerating rat liver
T2 - The relation between enzymes of heme synthesis and growth
AU - SCHOENFELD, Nili
AU - MAMET, Rivka
AU - EPSTEIN, Orit
AU - LAHAV, Meir
AU - LURIE, Yoav
AU - ATSMON, Abraham
PY - 1987/8
Y1 - 1987/8
N2 - Enzymes of heme synthesis, porphyrins and heme content of regenerating rat livers were examined. During the first three days of regeneration the weights of livers of one‐third and two‐third hepatectomized rats increased 1.5‐fold and 2.7‐fold and the activity of porphobilinogen deaminase increased 2‐fold and 4‐fold and was inversely correlated with ferrochelatase activity. δ‐Aminolevulinic acid synthase and δ‐aminolevulinic acid dehydratase activities were reduced. Concomitantly an increase in the concentration of porphyrins and a decrease in that of heme were observed. The changes in the biosynthetic pathway of heme during rapid growth of the liver are discussed.
AB - Enzymes of heme synthesis, porphyrins and heme content of regenerating rat livers were examined. During the first three days of regeneration the weights of livers of one‐third and two‐third hepatectomized rats increased 1.5‐fold and 2.7‐fold and the activity of porphobilinogen deaminase increased 2‐fold and 4‐fold and was inversely correlated with ferrochelatase activity. δ‐Aminolevulinic acid synthase and δ‐aminolevulinic acid dehydratase activities were reduced. Concomitantly an increase in the concentration of porphyrins and a decrease in that of heme were observed. The changes in the biosynthetic pathway of heme during rapid growth of the liver are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0023643182&partnerID=8YFLogxK
U2 - 10.1111/j.1432-1033.1987.tb13564.x
DO - 10.1111/j.1432-1033.1987.tb13564.x
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0023643182
SN - 0014-2956
VL - 166
SP - 663
EP - 666
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
IS - 3
ER -