The heme biosynthetic pathway in the regenerating rat liver: The relation between enzymes of heme synthesis and growth

Nili SCHOENFELD, Rivka MAMET, Orit EPSTEIN, Meir LAHAV, Yoav LURIE, Abraham ATSMON

Research output: Contribution to journalArticlepeer-review

Abstract

Enzymes of heme synthesis, porphyrins and heme content of regenerating rat livers were examined. During the first three days of regeneration the weights of livers of one‐third and two‐third hepatectomized rats increased 1.5‐fold and 2.7‐fold and the activity of porphobilinogen deaminase increased 2‐fold and 4‐fold and was inversely correlated with ferrochelatase activity. δ‐Aminolevulinic acid synthase and δ‐aminolevulinic acid dehydratase activities were reduced. Concomitantly an increase in the concentration of porphyrins and a decrease in that of heme were observed. The changes in the biosynthetic pathway of heme during rapid growth of the liver are discussed.

Original languageEnglish
Pages (from-to)663-666
Number of pages4
JournalEuropean Journal of Biochemistry
Volume166
Issue number3
DOIs
StatePublished - Aug 1987

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