@article{400c236f0328405c8e60ba0f79e22e23,
title = "The heme biosynthetic pathway in lymphocytes of patients with malignant lymphoproliferative disorders",
abstract = "The metabolism of heme is impaired in lymphocytes of patients with malignant lymphoproliferative disorders (MLPO). Two of the enzymes of the heme biosynthetic pathway, delta-aminolevulinic acid dehydrase (ALAD) (EC 4.2.1.24) and ferrochelatase (FC) (EC 4.99.1.1) are markedly reduced. The activity of porphobilinogen deaminase (PBGD) (EC 4.3.1.8) is increased. The rate-limiting enzyme of heme biosynthesis in the liver, aminolevulinate synthase (ALAS) (EC 2.3.1.37) remains unchanged although the concentration of total heme in the lymphocytes is markedly reduced. This might reflect a lack of negative feedback inhibition by heme on ALAS activity in this system.",
keywords = "aminolevulinate synthase, heme, lymphocytes, malignant lymphoproliferative disorders",
author = "N. Schoenfeld and O. Epstein and M. Lahav and R. Mamet and M. Shaklai and A. Atsmon",
note = "Funding Information: We would like to thank Mrs. R. Mevaser for excellent technical assistance and Mrs. N. Reich for help in obtaining consent and blood samples from patients.This work was supported by the Israel Cancer Association and the generous financial assistance of Mr. and Mrs. D. Sala.",
year = "1988",
month = dec,
day = "1",
doi = "10.1016/0304-3835(88)90211-X",
language = "אנגלית",
volume = "43",
pages = "43--48",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1-2",
}