The heart matters: Contribution of genetic factors in recurrent pericarditis

Carlo Perricone, Daphna Katz, Cinzia Ciccacci, Fulvia Ceccarelli, Guido Valesini, Yehuda Shoenfeld, Paola Borgiani, Fabrizio Conti

Research output: Contribution to journalReview articlepeer-review

Abstract

Recurrent pericarditis is a state of repetitive inflammation of the pericardium with intervals of remission. The etiology of recurrent pericarditis is still largely unknown, yet most causes are presumed to be immune mediated. Genetic factors, including human leukocyte antigen (HLA) haplotypes, can be involved in dysregulation of the immune system and as a predisposition to several autoimmune conditions, including recurrent pericarditis. Several diseases are frequently associated with such manifestations. They include systemic lupus erythematosus, familial Mediterranean fever, and tumor necrosis factor receptor-associated periodic syndrome. However, idiopathic recurrent pericarditis remains the most frequently observed clinical condition and the conundrum of this disease still needs to be solved.

Original languageEnglish
Pages (from-to)487-490
Number of pages4
JournalIsrael Medical Association Journal
Volume21
Issue number7
StatePublished - Jul 2019

Keywords

  • Familial Mediterranean fever (FMF)
  • Idiopathic recurrent acute pericarditis (IRAP)
  • Pericarditis
  • Systemic lupus erythematosus (SLE)
  • Tumor necrosis factor receptor-associated periodic syndrome (TRAPS)

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