The gonadotropin-releasing hormone receptor: Signals involved in gonadotropin secretion and biosynthesis

H. Dan-Cohen; D. Ben-Menahem; Z. Naor

doi:10.1159/000181488

The gonadotropin-releasing hormone receptor: Signals involved in gonadotropin secretion and biosynthesis

H. Dan-Cohen, D. Ben-Menahem, Z. Naor^*

^*Corresponding author for this work

Biochemistry Molecular Biology

Research output: Contribution to journal › Article › peer-review

Abstract

The neurohormone gonadotropin-releasing hormone (GnRH) is a decapeptide which is synthesized in the hypothalamus and released into the hypophysial portal system in a pulsatile manner. GnRH exerts its effect on the anterior pituitary gonadotrophs where it regulates the secretion and synthesis of gonadotropins (luteinizing hormone and follicle-stimulating hormone) through receptor-mediated actions. The GnRH receptor has been characterized and shown to be coupled to the formation of ‘second messengers’ which participate in signal transduction mechanisms. GnRH stimulation of luteinizing hormone release is a Ca²⁺-dependent process. G protein, phosphoinositide hydrolysis, protein kinase C as well as arachidonic acid and some of its metabolites were identified as possible mediators in the process.

Original language	English
Pages (from-to)	76-86
Number of pages	11
Journal	Hormone Research in Paediatrics
Volume	33
Issue number	2-4
DOIs	https://doi.org/10.1159/000181488
State	Published - 1990

Keywords

G protein
Gene expression
Gonadotropin
LH mRNA
Phosphoinositide turnover
Protein kinase C

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abstract = "The neurohormone gonadotropin-releasing hormone (GnRH) is a decapeptide which is synthesized in the hypothalamus and released into the hypophysial portal system in a pulsatile manner. GnRH exerts its effect on the anterior pituitary gonadotrophs where it regulates the secretion and synthesis of gonadotropins (luteinizing hormone and follicle-stimulating hormone) through receptor-mediated actions. The GnRH receptor has been characterized and shown to be coupled to the formation of {\textquoteleft}second messengers{\textquoteright} which participate in signal transduction mechanisms. GnRH stimulation of luteinizing hormone release is a Ca2+-dependent process. G protein, phosphoinositide hydrolysis, protein kinase C as well as arachidonic acid and some of its metabolites were identified as possible mediators in the process.",

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AU - Ben-Menahem, D.

AU - Naor, Z.

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KW - Gene expression

KW - Gonadotropin

KW - LH mRNA

KW - Phosphoinositide turnover

KW - Protein kinase C

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The gonadotropin-releasing hormone receptor: Signals involved in gonadotropin secretion and biosynthesis

Abstract

Keywords

UN SDGs

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