The gonadotropin-releasing hormone receptor: Signals involved in gonadotropin secretion and biosynthesis

H. Dan-Cohen, D. Ben-Menahem, Z. Naor

Research output: Contribution to journalArticlepeer-review

Abstract

The neurohormone gonadotropin-releasing hormone (GnRH) is a decapeptide which is synthesized in the hypothalamus and released into the hypophysial portal system in a pulsatile manner. GnRH exerts its effect on the anterior pituitary gonadotrophs where it regulates the secretion and synthesis of gonadotropins (luteinizing hormone and follicle-stimulating hormone) through receptor-mediated actions. The GnRH receptor has been characterized and shown to be coupled to the formation of ‘second messengers’ which participate in signal transduction mechanisms. GnRH stimulation of luteinizing hormone release is a Ca2+-dependent process. G protein, phosphoinositide hydrolysis, protein kinase C as well as arachidonic acid and some of its metabolites were identified as possible mediators in the process.

Original languageEnglish
Pages (from-to)76-86
Number of pages11
JournalHormone Research in Paediatrics
Volume33
Issue number2-4
DOIs
StatePublished - 1990

Keywords

  • G protein
  • Gene expression
  • Gonadotropin
  • LH mRNA
  • Phosphoinositide turnover
  • Protein kinase C

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